Epitalon (Epithalone or Epithalon) High Purity & USA Manufactured
Epitalon, also known as Epithalone or Epithalon, is a synthetic version of Epithalamin, a polypeptide naturally produced in the pineal gland.
The Epitalon peptide was discovered many years back by the Russian scientist Professor Vladimir Khavinson[i]. He carried out epitalon-related research for the following 35 years in both animal and mice trials.
Primarily, the role of Epitalon is to increase natural production of telomerase. Telomerase is a natural enzyme that enables cells to reproduce telomeres – the protective parts of our DNA. In turn, this promotes the replication of DNA in order for the body to grow new cells and rejuvenate the old cells.
Younger mice produce more telomerase than older mice. In addition, they produce longer telomeres which leads to better cell health and replication.
As mice age, telomerase production decreases and subsequently leads to cell replication decline. That’s where Epitalon comes in.
What Does Epitalon Do?
Epitalon definition: a mini protein that stimulates the production of telomerase.
How does Epitalon work? It works by regulating metabolism, heightening sensitivity of hypothalamus, stabilizing the function of the anterior pituitary and regulating melatonin levels in the body, as research on animals has shown.
Epithalon peptide[ii] has a unique make-up of organisms determined by double-stranded DNA in the nucleus of the cells. At the tip of those DNA strands, you’ll find telomeres. They are responsible for preventing genetic information loss resulting from chromosome-shortening which happens with every cell separation.
Each time a cell separates, its replication is incomplete and consequently, telomeres get shorter. The more this happens, the more the telomeres shorten.
Numerous studies show that this shortening is linked to a slew of age-related diseases including cardiovascular disease and even early mortality in mice.
Known as the Epitalon fountain of youth due to its longevity effects, a high level of Epitalon results in overall wellness and wellbeing.
Effects of Epitalon
According to many studies[iii] conducted on both animals and mices, Epitalon is a substance biologically identical to the one produced by the mice body. It can set the biological body clock of cells to zero in order for the cells to regain the reestablishment of optimal organ function and repair the body’s tissues.
Epitalon is a biopeptide created from four gero-protective amino acids (tetrapeptide: L-alanyl-l-glutamyl-l-asparagyl-glycine), which can be administered orally, intra-nasally, parenterally, sublingually, and also topically.
Russian researchers have discovered a lot about epithalon in recent years. For instance, they now know that it can reactivate telomerase production in cells. Furthermore, they know that it can also rejuvenate the whole body and promote health. They’ve even discovered that it can address the source of ageing.
Benefits of Epitalon Peptide
Scientific research proves that there are a number of Epitalon benefits. In short, these are the beneficial health effects of Epitalon peptide, as research on animals has shown:
- Increases longevity and mice lifespan
- Prevents age-related diseases such as dementia, heart disease, and cancer in animals
- Promotes deeper sleep
- Improved skin health
- Strengthens muscle cells
- Speeds up healing
- Reduces lipid oxidation and reactive oxygen species
- Increases resistance to emotional stress
- Stabilizes melatonin levels in mice
Of course, robust research must be carried out on this protein in order to fully understand its full affects. However, from what scientists have uncovered about epithalon, it seems likely that it will soon be available for use to treat and cure a number of health issues. Remarkably, scientists believe that Epitalon could soon be used as a treatment and a preventative medicine against cancer.
To further understand the health benefits of Epitalon peptide, we’re going to take a deeper look at its benefits and full scope of potential uses.
Epitalon Anti-Aging Effects
In 1992, Professor Vladimir Dilmice and Dr. Ward Dean co-authored a paper entitled “The neuroendocrine theory of aging and degenerative disease,” which showed that biopeptide epitalon can increase the lifespan of rats by 25%.
These findings were then confirmed by various subsequent studies carried out by Professor Vladimir Khavinson, President of the St Petersburg Institute of Bio-regulation.
As discovered by these researchers, Epitalon increases lifespan thanks to its ability to connect several amino acids by peptide bonds. This can also stimulate brain activity and reduce tumor formations.
After 15 years of clinical observation, Khavinson’s research on mice showed that biopeptides significantly improved physiological function and decreased mortality by approximately 50%.
He also demonstrated that the epithalon biopeptide DNA interactions could control genetic functions and consequently successfully extend life expectancy.
Research shows that mice given Epitalon from the age of three months until their natural death increased their lifespan compared to mice given placebo. Epitalon treatment also lowered the frequency of chromosome abnormalities in the subjects’ bone marrow cells. Treatment with Epitalon also prevented leukaemia development in mice. Overall, the results of the study suggest that this peptide offers a powerful anti-aging effect and is safe for long-term use.
Numerous animal studies show that taking Epitalon results in the following effects:
- Regulated production of cortisol and melatonin in aging monkey, helping to stabilize the rhythm of cortisol secretion.
- Protected reproductive system and corrected impairment in the reproductive systems of rats.
- Preserved structure of the retina in retinitis pigmentosa.
- Inhibited proliferation of colon tumors in rats.
Epitalon Skin Effects
In addition to its anti-aging effects, Epitalon promotes better skin health, as research on animals has shown.
Research by Dr Khavinson shows that epithalon can activate the cells[iv] responsible to repairing and maintaining the extracellular matrix that keeps skin healthy and youthful. The extracellular matrix is where collagen and elastin can be found – the two anti-aging powerhouses.
While there are a number of skin aging creams that claim to strengthen collagen in the skin, they do not penetrate the skin as deeply as Epitalon. Epithalon penetrates the cells themselves and promotes both growth and development of the fibroblasts that make proteins like collagen. In turn, this leads to optimum skin regeneration.
But it’s not just the vanity side of aging that epithalon peptide helps. It can also ward off disease, infection and damage. Aged skin is prone to tears and being brittle. Epitalon used on the skin can ward off those symptoms.
Epitalon for Retinitis Pigmentosa
Retinitis pigmentosa is a degenerative eye disease that leads to the degeneration of the rods in the retina. Rods are a type of receptor in the eye that convert light into chemical signals. In a clinic trial, research showed that Epitalon improved degenerative damage to the retina caused by the condition.
In studies on rats, Epitalon advances the function of retinal cells by preventing degeneration and preserving the rod structure.
As per a study on mices and rats, it proves that Epitalon is an effective treatment for retinitis pigmentosa. Still, further research is needed to confirm the findings.
Epitalon Sleep Effects
Epitalon can allegedly correct circadian rhythms. In case you are wondering, what are circadian rhythms, let us explain.
Essentially, circadian rhythms are mental, physical and behavioral changes that follow a daily cycle. Circadian rhythms respond mainly to light and darkness, which is why sleeping at night and being awake in the day is a good example of a light-related circadian rhythm. Nearly all living things have them – mice, animals, plants and even tiny microbes.
However, as animals age, those rhythms get disrupted and less prominent, due to decreased melatonin secretion.
In a small study on 14 elderly mice[v], epitalon significantly improved melatonin production. It also altered its cycle to mimic those of young mice.
Another study on aging monkeys also showed how Epitalon stimulated evening melatonin secretion and corrected the biological rhythm.
And because they determine our sleep patterns, it appears clear that Epitalon improves sleep dramatically in the process. Thus, Epitalon supplementation may improve the overall sleep quality and patterns, as research on animals has shown.
Epitalon for Cancer
Epitalon research is still mainly in the animal stage and further mice studies are required in order to better understand this peptide. However, research shows that Epitalon as a cancer treatment and for cancer prevention can be extremely effective. Of course, you should not attempt to replace conventional cancer therapies with this protein. Still, it is interesting to see how beneficial its effects are on a number of health conditions.
According to studies on rats, Epitalon peptide increases lymph flow and apoptosis while slowing down cancer growth.
In mice with mammary tumors, Epitalon reduced the number of mice with multiple tumors and reduced the maximum size of the tumors. Researchers also learned that peptide Epitalon decreased the expression of certain genes that can play a key role in the development of certain cancers such as breast cancer in both mice and mices.
Meanwhile, an additional study in mice found that Epitalon treatment reduced the number of mice with cancerous tumors. It also prevented cancer from moving to another location in the body — most interestingly, in all of the treated mice. As for the mice that did not receive the Epitalon administration, metastases were observed in 3 out of the 9.
How Is Epitalon Used?
While many results of Epitalon are promising and certainly show a lot of beneficial effects, the majority of research has been conducted in animals. In other words, Epitalon research remains largely unresearched.
For this reason, Epitalon is not FDA approved. That doesn’t mean it is dangerous to use, but it does mean it hasn’t yet received the sufficient research needed to approve it for consumption.
Overall, Epitalon antiaging effects especially look interesting and indeed, promising. Clearly the studies on animals show how effective Epitalon is for increasing lifespan and promoting youthfulness. It also appears to be a promising cancer prevention drug as tests in animals has shown.
Side Effects of Epitalon
According to over 100 scientific studies on Epitalon, there were no adverse reactions to this peptide. Of course, as with all drugs, Epitalon side effects may occur in certain animals.
Currently not yet approved by the FDA, Epitalon should only be purchased and used by scientific professionals for research purposes only.
Fortunately, it is considered a safe drug with no dangerous side effects. Nevertheless, the research on Epitalon continues in order to ensure its full safety and scope of benefits.
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Author info and References
Author info: The information provided in this article was taken from studies carried out by recognized researchers, including Anisimov, Vladimir N., and Vladimir Kh. Khavinson, Frolov, D. S., D. A. Sibarov, and A. B. Vol’nova, Khavinson, V., Diomede, F., Mironova, E., Linkova, N., Trofimova, S., Trubiani, O., Sinjari, B., Chalisova, N. I., N. S., Zhekalov, A. O. Orlova, G. A. Ryzhak, Shatilo, and L. V. Magdich.
[i] Anisimov, Vladimir N., and Vladimir Kh. Khavinson. “Peptide Bioregulation of Aging: Results and Prospects.” Biogerontology 11, no. 2 (October 15, 2009): 139–149. doi:10.1007/s10522-009-9249-8.
[ii] Frolov, D. S., D. A. Sibarov, and A. B. Vol’nova. “Altered Spontaneous Electric Activity Detected in Rat Motor Neocortex after Intranasal Epitalon Infusions.” PsycEXTRA Dataset (2004). doi:10.1037/e516032012-081.
[iii] Khavinson, V., Diomede, F., Mironova, E., Linkova, N., Trofimova, S., Trubiani, O., … Sinjari, B. (2020). AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules, 25(3), 609. doi:10.3390/molecules25030609
[iv] Chalisova, N. I., N. S. Linkova, A. N. Zhekalov, A. O. Orlova, G. A. Ryzhak, and V. Kh. Khavinson. “Short Peptides Stimulate Cell Regeneration in Skin During Aging.” Advances in Gerontology 5, no. 3 (July 2015): 176–179. doi:10.1134/s2079057015030054.
[v] Korkushko, O. V., V. Kh. Khavinson, V. B. Shatilo, and L. V. Magdich. “Effect of Peptide Preparation Epithalamin on Circadian Rhythm of Epiphyseal Melatonin-Producing Function in Elderly People.” Bulletin of Experimental Biology and Medicine 137, no. 4 (April 2004): 389–391. doi:10.1023/b:bebm.0000035139.31138.bf.
Epitalon Research Peptides Scientists
Product Usage: THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. This product has not been approved by the FDA for Human Use. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.