Humanin Peptide: Everything You Need to Know
Humanin (HN) is a polypeptide and a naturally occurring micro-peptide which suppresses neuronal cell death induced by various Alzheimer’s disease genes as studies showed. The Humanin peptide is encoded in the mitochondrial DNA[i] and functions as a cytoprotective protein, protecting cells from apoptosis. Apoptosis is programmed cell death. By protecting the cells from this lethal process, it keeps the cells healthy and protects neurons, muscle cells, cardiac tissue, and the retina of the eye as tests showed.
Research shows that humanin treatment can improve cardiovascular disease and Alzheimer’s disease. With more extensive research, it could soon become an available over-the-counter medication for such health conditions.
In this article, we’re going to explore more about humanin peptide, what it does, its side effects, and where you can buy humanin for your research online.
What is Humanin Peptide?
Humanin is a micro-peptide, which means it is produced by short, open reading frames and does not undergo modification once produced. According to studies, this type of peptide ranges in size from 100-150 amino acids in length.
At only 24 amino acids in length, Humanin is actually one of the smallest micro peptides available. Its main feature is its interaction with the Bax protein to regulate apoptosis, eliminating its function of it when needed to preserve cells.
Research indicates[ii] that HN levels are typically lower in male mice than in female mice. It is important that there is a balanced humanin level in order for the body to function healthily. Too low or too high levels can result in a number of health issues.
Low humanin levels can lead to or may be an indicator of:
- Alzheimer’s disease
- Vision loss
- Insulin resistance
- Mitochondrial dysfunction
- Vascular dysfunction
High mice levels can lead to or may be an indicator of:
- Certain cancers
Drawing from clinical research, there are a number of benefits of humanin peptide. Even though research is limited regarding humanin benefits, there’s still sufficient research to confirm the following effects of this peptide.
Humanin and Longevity
Research has shown, Growth hormone (GH) negatively impacts HN peptide levels. For instance, research shows[iii] that mice who could not produce sufficient amounts of GH had higher levels of HN and lived longer than mice who did not produce adequate GH.
Additional research shows that animals of centenarians have 3x higher amounts of humanin than controls.
What’s more, HN can control cell death, enhance insulin sensitivity, lower inflammation, inhibit cell death, and degrade atherosclerotic plaques.
This suggests that humanin supplement may enhance longevity, as recent tests showed.
Humanin and Neuroprotection
Research in rats[iv] shows that humanin protects against programmed cell death in specific situations. For example, the peptide can protect neurons in the setting of Alzheimer’s disease, preventing cell death caused by beta-amyloid plaque build-up. Studies also indicate that humanin protects against excitotoxic neuron death in research using NMDA pulses.
Scientists hope that humanin function in treating neurodegenerative disease like AD and other forms of dementia could be a near-future treatment with more robust research.
Clinical trials show that humanin protects neurons through two different mechanisms. Both of these mechanisms prevent mitochondria from stimulating the apoptosis pathway. By binding to the Bcl-2 stimulating proteins tBid and Bid, humanin blocks their function and closes down the apoptosis pathway.
New research from Argentina indicates that humanin is released by astrocytes to guard synapses in hippocampal neurons. Research has shown that humanin supplementation can be highly beneficial for older animals in preventing age-related declines like memory loss.
Humanin and Insulin Resistance
According to scientific research, HN can also inhibit pancreatic beta-cell death and enhance glucose tolerance in non-diabetic animal subjects. This suggests that humanin for diabetes type 1 and type 2 could be beneficial.
Additionally, humanin acts on the hypothalamus, increasing insulin sensitivity in the liver and balancing blood glucose levels, as tests showed.
In turn, humanin can treat obesity by preventing weight gain through increased glucose stimulated insulin release, recent studies showed.
Humanin and Heart Disease
Research reveals that humanin peptide helps to protect blood vessels from the aftermath of bad cholesterol, otherwise known as oxidized LDL cholesterol. It also interacts with the creation of free radicals in response to LDL oxidation, reducing the species in the vasculature by 50%. Interestingly, it also lessens apoptosis by 50%.
Because humanin levels decline with age, it is crucial to keep them stable in order to protect your health. New research shows that peptide humanin can serve as a diagnostic marker and a treatment for cardiovascular disease.
By enhancing AMPK and eNOS, Humanin can also ward off damage induced by left coronary occlusion, reducing oxidative stress in the body.
Humanin and Bone Health
Scientists have found that humanin usage may be beneficial to bones in two primary ways. The first way is by preventing the death of chondrocytes – the cells responsible for keeping bones strong. Simultaneously, humanin results in promoted chondrocyte development, reducing osteoclast formation. To sum up, osteoclasts are the cells that break down bone and romodel it. Over-activation of these cells leads to severe bone loss. So by preventing this formation, humanin supplements help reduce significant bone remodeling and loss, as studies showed.
Humanin and Eye Health
According to research, humanin plays a huge role in protecting the retinal pigment epithelium (RPE) in age-related Macular Degeneration (AMD). Of all the humanin health benefits, this one is quite significant from what clinical evidence suggests.
The RPE is a layer of the retina that nourishes the cells responsible for vision. It also absorbs lights, filters blood components in the eye, and establishes a healthy nature of the inner eye.
Humanin prevents AMD by protecting against oxidative stress and cell death of RPE by heightening mitochondrial levels.
Supplementation with humanin can allegedly improve RPE function and enhance the tissue’s resitance to apoptosis. With more mice trials, scientists hope that they can establish a more effective treatment for retinal diseases like AMD.
Other Benefits of Humanin Peptide
But that’s not all. According to research, there are many other proven health benefits of humanin peptide. Here are the main ones noted as of May 2023:
- Combats weight gain and obesity
- Improves short-term memory
- Fights Huntington’s Disease
- Helps with amyotrophic lateral sclerosis
- Protects against sunburn
To date, humanin clinical trials are still limited. Scientists need to continue with their research on this micropeptide in order to gain a full understanding of its total list of benefits.
Can You Increase Humanin Naturally?
While humanin peptide supplement is one of the most effective ways to increase humanin in the body, there are ways you can naturally increase it without taking supplements. Let’s take a look at what they are.
- Exercise – resistance training increases levels of HN in skeletal muscle.
- Fasting – this not only suppresses IGF 1, but enhances humanin.
- B Vitamins – eating enough B vitamins can increase levels of humanin.
- Zinc – another effective vitamin for enhancing HN.
By implementing these natural humanin boosters, you can increase humanin without taking supplements or injections.
Humanin Side Effects
Is humanin safe? Or is humanin dangerous?
Fortunately, humanin is a safe chemical with minimal side effects, as studies showed. The research may be limited and it may not be legal to buy for consumption, but scientists do consider humanin safety to be high.
Please note it may have negative effects on cancer and pregnant mice.
In terms of humanin effects on cancer, it may contribute to certain cancers such as prostate cancer, bladder cancer, and pituitary cancer.
In terms of humanin pregnancy effects, high HN levels are often seen in females mice with pre-eclampsia. This may be due to high levels of oxidative stress in the body.
Is Humanin Legal?
From what research shows, humanin is a legitimate potential treatment for a variety of health conditions ranging from Alzheimer’s to diabetes. However, it is not currently legal to buy humanin for consumption.
In order to purchase humanin peptide online, you will need to state that you are buying it for research purposes only.
While humanin gene peptide is considered safe, there’s simply not enough research to make it legal as an over-the-counter medicine.
That is why it is currently sold to licensed researchers only. Hopefully, with more robust research, it will be made into a legal drug for use.
Humanin Peptide for Sale 2023
Would you like to buy humanin peptide?
Look no further than Peptide Sciences, the chief vendor of humanin supplement to buy online. Made in the United States, you are guaranteed high purity humanin peptide when you order from this company.
They’ve made quite a name for themselves in the peptide’s world, mainly because they provide premium quality peptides at reasonable prices. This is achieved through high-performance liquid chromatography and detailed analysis, which certifies the purity, identity, and accuracy of each peptide.
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Author info and References
Author info: The information provided in this article was taken from studies carried out by recognized researchers, including Lee, Changhan, Kelvin Yen, and Pinchas Cohen, Lytvyn, Yuliya, Junxiang Wan, Vesta Lai, David Z.I. Cherney, Junxiang Wan, Brian Miyazaki, Yimin Fang, Jaime Guevara-Aguirre, Kelvin Yen, Valter Longo, Andrzej Bartke, Caricasole, Andrea, Valeria Bruno, Irene Cappuccio, Daniela Melchiorri, Agata Copani, and Ferdinando Nicoletti.
[i] Lee, Changhan, Kelvin Yen, and Pinchas Cohen. “Humanin : a Harbinger of Mitochondrial-Derived Peptides?” Trends in Endocrinology & Metabolism 24, no. 5 (May 2013): 222–228. doi:10.1016/j.tem.2013.01.005.
[ii] Lytvyn, Yuliya, Junxiang Wan, Vesta Lai, Pinchas Cohen, and David Z.I. Cherney. “The Effect of Sex on Humanin Levels in Healthy Mice and Patients with Uncomplicated Type 1 Diabetes Mellitus.” Canadian Journal of Physiology and Pharmacology 93, no. 4 (April 2015): 239–243. doi:10.1139/cjpp-2014-0401.
[iii] Lee, Changhan, Junxiang Wan, Brian Miyazaki, Yimin Fang, Jaime Guevara-Aguirre, Kelvin Yen, Valter Longo, Andrzej Bartke, and Pinchas Cohen. “IGF-I Regulates the Age-Dependent Signaling Peptide Humanin .” Aging Cell 13, no. 5 (July 18, 2014): 958–961. doi:10.1111/acel.12243.
[iv] Caricasole, Andrea, Valeria Bruno, Irene Cappuccio, Daniela Melchiorri, Agata Copani, and Ferdinando Nicoletti. “A Novel Rat Gene Encoding a Humanin ‐like Peptide Endowed with Broad Neuroprotective Activity.” The FASEB Journal 16, no. 10 (June 21, 2002): 1331–1333. doi:10.1096/fj.02-0018fje.
Humanin Peptide Research Peptides Scientists
- Christoph Buettner, MD, PhD Humanin
Professor in the Division of Endocrinology, Diabetes and Bone Disease in the Department of Medicine. Dr. Buettner is also Associate Director for Research in Type 2 Diabetes at the Diabetes, Obesity and Metabolism Institute (DOMI), and Professor in the Department of Neuroscience. He is board certified in Endocrinology, Metabolism and Diabetes and Internal Medicine. He is a member of numerous grant review panels, editorial boards, and has been elected to the American Society of Clinical Investigation.
Christoph Buettner has a M.D from the Ludwig Maximillians University. Christoph Buettner, MD, PhD currently works at the Icahn School of Medicine at Mount Sinai and has 3 years experience in researching Decline in Humanin with age at the Albert Einstein College of Medicine. One of their notable works include "Humanin: A Novel Central Regulator of Peripheral Insulin Action". Published online 22 Jul 2009. doi:https://doi.org/10.1371/journal.pone.0006334 [PubMed]
Icahn School of Medicine | Research Gate | Doximity
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