Epitalon, also known as Epithalone or Epithalon, is a synthetic variant of Epithalamin, a polypeptide produced in the pineal gland. Russian scientist Vladimir Khavinson discovered that it enhances the natural production of telomerase, an enzyme that helps cells reproduce telomeres, vital for DNA replication and cell rejuvenation.
Epitalon works by regulating metabolism, increasing hypothalamus sensitivity, stabilizing the anterior pituitary function, and managing melatonin levels. It is especially important in preventing telomere shortening, which is linked to age-related diseases, including cardiovascular disease.
Research shows that Epitalon has several health benefits, including increased longevity, prevention of age-related diseases, improved skin health, and resistance to emotional stress. It is composed of four gero-protective amino acids and can be administered in various ways.
The anti-ageing effects of Epitalon are significant, as it can extend the lifespan of rats by 25% by stimulating brain activity and reducing tumour formation. It also preserves the structure of the retina, protects the reproductive system, and regulates cortisol production.
Epitalon can also repair and maintain the extracellular matrix that keeps skin healthy and youthful, and it can improve the function of retinal cells in retinitis pigmentosa. It’s also believed to correct circadian rhythms, improving sleep quality and patterns.
Research suggests that Epitalon could also potentially be used in cancer treatment and prevention due to its effectiveness in slowing down cancer growth. However, Epitalon is not yet FDA-approved and requires further research to fully understand its effects and potential uses.
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Essential Amino Acids Your body requires 20 different amino acids to function optimally. However, only nine amino acids are considered essential: histidine, isoleucine, leucine, tryptophan, valine, lysine, methionine, phenylalanine, and threonine. Nonessential Amino Acids Nonessential amino acids include: alanine, arginine, asparagine, aspartic acid, glycine, proline, serine, tyrosine, cysteine, glutamic acid, and glutamine. Conditionally Essential Amino Acids Conditional amino acids are mainly essential in times of illness and stress. These acids include: arginine, cysteine, glutamine, ornithine, proline, serine, tyrosine, and glycine. What is a Polypeptide? Polypeptides are chains of amino acids[ii] linked together by protein bonds. Short polypeptides are named based on the number of monomeric amino acids that make them. For example, a dipeptide is comprised of two amino acids sub-units and a tetrapeptide is made of four amino acid sub-units.
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Epitalon (Epithalone or Epithalon) High Purity & USA Manufactured
Epitalon, also known as Epithalone or Epithalon, is a synthetic version of Epithalamin, a polypeptide naturally produced in the pineal gland.
The Epitalon peptide was discovered many years back by the Russian scientist Professor Vladimir Khavinson[i]. He carried out epitalon-related research for the following 35 years in both animal and mice trials.
Primarily, the role of Epitalon is to increase natural production of telomerase. Telomerase is a natural enzyme that enables cells to reproduce telomeres – the protective parts of our DNA. In turn, this promotes the replication of DNA in order for the body to grow new cells and rejuvenate the old cells.
Younger mice produce more telomerase than older mice. In addition, they produce longer telomeres which leads to better cell health and replication.
As mice age, telomerase production decreases and subsequently leads to cell replication decline. That’s where Epitalon comes in.
What Does Epitalon Do?
Epitalon definition: a mini protein that stimulates the production of telomerase.
How does Epitalon work? It works by regulating metabolism, heightening the sensitivity of hypothalamus, stabilizing the function of the anterior pituitary and regulating melatonin levels in the body, as research on animals has shown.
Epithalon peptide[ii] has a unique make-up of organisms determined by double-stranded DNA in the nucleus of the cells. At the tip of those DNA strands, you’ll find telomeres. They are responsible for preventing genetic information loss resulting from chromosome shortening, which happens with every cell separation.
Each time a cell separates, its replication is incomplete and consequently, telomeres get shorter. The more this happens, the more the telomeres shorten.
Numerous studies show that this shortening is linked to a slew of age-related diseases, including cardiovascular disease and even early mortality in mice.
Known as the Epitalon fountain of youth due to its longevity effects, a high level of Epitalon results in overall wellness and well-being.
Effects of Epitalon
According to many studies[iii] conducted on both animals and mice, Epitalon is a substance biologically identical to the one produced by the mice’s body. It can set the biological body clock of cells to zero in order for the cells to regain the reestablishment of optimal organ function and repair the body’s tissues.
Epitalon is a biopeptide created from four gero-protective amino acids (tetrapeptide: L-alanyl-l-glutamyl-l-asparagyl-glycine), which can be administered orally, intra-nasally, parenterally, sublingually, and also topically.
Russian researchers have discovered a lot about epithalon in recent years. For instance, they now know that it can reactivate telomerase production in cells. Furthermore, they know that it can also rejuvenate the whole body and promote health. They’ve even discovered that it can address the source of ageing.
Benefits of Epitalon Peptide
Scientific research proves that there are a number of Epitalon benefits. In short, these are the beneficial health effects of Epitalon peptide, as research on animals has shown:
Increases longevity and mice lifespan
Prevents age-related diseases such as dementia, heart disease, and cancer in animals
Promotes deeper sleep
Improved skin health
Strengthens muscle cells
Speeds up healing
Reduces lipid oxidation and reactive oxygen species
Increases resistance to emotional stress
Stabilizes melatonin levels in mice
Of course, robust research must be carried out on this protein in order to fully understand its full effects. However, from what scientists have uncovered about epithalon, it seems likely that it will soon be available for use to treat and cure a number of health issues. Remarkably, scientists believe that Epitalon could soon be used as a treatment and preventative medicine against cancer.
To further understand the health benefits of Epitalon peptide, we’re going to take a deeper look at its benefits and full scope of potential uses.
Epitalon Anti-Aging Effects
In 1992, Professor Vladimir Dilmice and Dr. Ward Dean co-authored a paper entitled “The neuroendocrine theory of ageing and degenerative disease,” which showed that biopeptide epitalon can increase the lifespan of rats by 25%.
These findings were then confirmed by various subsequent studies carried out by Professor Vladimir Khavinson, President of the St Petersburg Institute of Bio-regulation.
As discovered by these researchers, Epitalon increases lifespan thanks to its ability to connect several amino acids by peptide bonds. This can also stimulate brain activity and reduce tumour formation.
After 15 years of clinical observation, Khavinson’s research on mice showed that biopeptides significantly improved physiological function and decreased mortality by approximately 50%.
He also demonstrated that the epithalon biopeptide DNA interactions could control genetic functions and consequently successfully extend life expectancy.
Research shows that mice were given Epitalon from the age of three months until their natural death increased their lifespan compared to mice given a placebo. Epitalon treatment also lowered the frequency of chromosome abnormalities in the subjects’ bone marrow cells. Treatment with Epitalon also prevented leukaemia development in mice. Overall, the results of the study suggest that this peptide offers a powerful anti-ageing effect and is safe for long-term use.
Numerous animal studies show that taking Epitalon results in the following effects:
Regulated production of cortisol and melatonin in ageing monkeys, helping to stabilize the rhythm of cortisol secretion.
Protected reproductive system and corrected impairment in the reproductive systems of rats.
Preserved structure of the retina in retinitis pigmentosa.
The inhibited proliferation of colon tumours in rats.
Epitalon Skin Effects
In addition to its anti-ageing effects, Epitalon promotes better skin health, as research on animals has shown.
Research by Dr Khavinson shows that epithalon can activate the cells[iv] responsible to repairing and maintaining the extracellular matrix that keeps skin healthy and youthful. The extracellular matrix is where collagen and elastin can be found – the two anti-ageing powerhouses.
While there are a number of skin ageing creams that claim to strengthen collagen in the skin, they do not penetrate the skin as deeply as Epitalon. Epithalon penetrates the cells themselves and promotes both the growth and development of the fibroblasts that make proteins like collagen. In turn, this leads to optimum skin regeneration.
But it’s not just the vanity side of ageing that epithalon peptide helps. It can also ward off disease, infection and damage. Aged skin is prone to tears and is brittle. Epitalon used on the skin can ward off those symptoms.
Epitalon for Retinitis Pigmentosa
Retinitis pigmentosa is a degenerative eye disease that leads to the degeneration of the rods in the retina. Rods are a type of receptor in the eye that convert light into chemical signals. In a clinical trial, research showed that Epitalon improved degenerative damage to the retina caused by the condition.
In studies on rats, Epitalon advances the function of retinal cells by preventing degeneration and preserving the rod structure.
As per a study on mice and rats, it proves that Epitalon is an effective treatment for retinitis pigmentosa. Still, further research is needed to confirm the findings.
Epitalon Sleep Effects
Epitalon can allegedly correct circadian rhythms. In case you are wondering, what are circadian rhythms, let us explain.
Essentially, circadian rhythms are mental, physical and behavioural changes that follow a daily cycle. Circadian rhythms respond mainly to light and darkness, which is why sleeping at night and being awake during the day is a good example of a light-related circadian rhythm. Nearly all living things have them – mice, animals, plants and even tiny microbes.
However, as animals age, those rhythms get disrupted and less prominent due to decreased melatonin secretion.
In a small study on 14 elderly mice[v], epitalon significantly improved melatonin production. It also altered its cycle to mimic those of young mice.
Another study on ageing monkeys also showed how Epitalon stimulated evening melatonin secretion and corrected the biological rhythm.
And because they determine our sleep patterns, it appears clear that Epitalon improves sleep dramatically in the process. Thus, Epitalon supplementation may improve overall sleep quality and patterns, as research on animals has shown.
Epitalon for Cancer
Epitalon research is still mainly in the animal stage, and further mice studies are required in order to better understand this peptide. However, research shows that Epitalon as a cancer treatment and for cancer prevention can be extremely effective. Of course, you should not attempt to replace conventional cancer therapies with this protein. Still, it is interesting to see how beneficial its effects are on a number of health conditions.
According to studies on rats, Epitalon peptide increases lymph flow and apoptosis while slowing down cancer growth.
In mice with mammary tumours, Epitalon reduced the number of mice with multiple tumours and reduced the maximum size of the tumours. Researchers also learned that the peptide Epitalon decreased the expression of certain genes that can play a key role in the development of certain cancers, such as breast cancer in both mice and mice.
Meanwhile, an additional study in mice found that Epitalon treatment reduced the number of mice with cancerous tumours. It also prevented cancer from moving to another location in the body — most interestingly, in all of the treated mice. As for the mice that did not receive the Epitalon administration, metastases were observed in 3 out of the 9.
How Is Epitalon Used?
While many results of Epitalon are promising and certainly show a lot of beneficial effects, the majority of research has been conducted in animals. In other words, Epitalon research remains largely unresearched.
For this reason, Epitalon is not FDA-approved. That doesn’t mean it is dangerous to use, but it does mean it hasn’t yet received sufficient research needed to approve for consumption.
Overall, Epitalon antiaging effects especially look interesting and, indeed, promising. Clearly, the studies on animals show how effective Epitalon is for increasing lifespan and promoting youthfulness. It also appears to be a promising cancer-prevention drug, as tests in animals have shown.
Side Effects of Epitalon
According to over 100 scientific studies on Epitalon, there were no adverse reactions to this peptide. Of course, as with all drugs, Epitalon side effects may occur in certain animals.
Currently not yet approved by the FDA, Epitalon should only be purchased and used by scientific professionals for research purposes only.
Fortunately, it is considered a safe drug with no dangerous side effects. Nevertheless, the research on Epitalon continues in order to ensure its full safety and scope of benefits.
Epitalon Video
Advantages of Epitalon Peptide
Epitalon, also known by names such as Epithalone, Epithalon, Epithalamin, Epithalamin Peptide, Epitalom, Epitalon acetate, and Peptide Epitalon, possesses unique properties that make it highly advantageous for research purposes. One notable property is its ability to bind and inhibit activin, a protein that plays a critical role in regulating cell growth and differentiation. This binding capacity of Epitalon enables researchers to study its potential effects on various cellular processes and uncover possible therapeutic applications in a more in-depth manner.
Epitalon Benefits
Epitalon has exhibited a broad range of benefits in non-human research studies. These include promoting cell proliferation, reducing oxidative stress, modulating immune responses, and extending the lifespan of model organisms. These benefits position Epitalon as a promising candidate for various research applications, particularly in the fields of ageing, regenerative medicine, and immunology.
Epitalon Before and After in Research
Observations of Epitalon in Research: Before and After have shown significant changes in animal models, such as improved overall health and increased lifespan. Some of the most striking findings include accelerated wound healing, reduced inflammation, and enhanced cognitive function. These observations emphasize the potential therapeutic applications of Epitalon in treating diverse medical conditions.
Epitalon Cycle for Research
An Epitalon Research Cycle typically involves administering the peptide for a specific duration, often ranging from a few weeks to several months. The frequency of administration may vary depending on the research goals and the animal model being used. Researchers should take into account factors such as the desired outcome, potential side effects, and the optimal timing of administration to ensure the best possible results.
Epitalon Dosage for Research
Determining the appropriate Epitalon peptide injection dosage is crucial for obtaining meaningful results in non-human research applications. To establish an effective dosing protocol, researchers should consider factors such as the specific animal model and the desired outcome. Starting with a low dosage and gradually adjusting based on observed effects is generally recommended. It is essential to monitor any side effects to ensure the safety and well-being of the animal subjects while optimizing the Epitalon dosage protocol.
How to Use Epitalon in Research
Proper Use of Epitalon in Research Studies involves careful handling and storage of the peptide to maintain its stability and effectiveness. Researchers should store Epitalon in a cool, dark place, ideally at -20°C, and avoid repeated freeze-thaw cycles. When administering Epitalon to animal models, it is crucial to use sterile techniques and follow appropriate safety precautions to minimize the risk of contamination and adverse reactions.
How to Mix Epitalon for Research
Mixing Guidelines for Epitalon in Research involves using bacteriostatic water or another suitable solvent to dissolve the peptide. Researchers should ensure a sterile environment to minimize contamination risks and follow proper mixing procedures to maintain the stability and effectiveness of the peptide.
Best Epitalon Results in Research
Some of the most notable Epitalon results in research include findings that showcase its potential for therapeutic applications. These results, such as improved wound healing, increased lifespan, and enhanced cognitive function, highlight the potential of Epitalon in addressing various medical conditions and emphasize its value as a research tool.
Epitalon Research Topics
Efficacy of Epitalon in Addressing Specific Conditions
In non-human research studies, Epitalon has demonstrated effectiveness for various conditions, including ageing, inflammation, immune dysregulation, and neurodegenerative diseases. These findings suggest that Epitalon may hold therapeutic potential for a wide range of medical applications and warrant further investigation.
Epitalon Peptide’s Role in Cellular and Molecular Biology Research
Researchers have utilized Epitalon to study cellular and molecular mechanisms underlying its effects, such as modulation of gene expression, cell signalling pathways, and antioxidant responses. These studies have yielded valuable insights into the potential mechanisms of action of Epitalon, contributing to our understanding of its therapeutic potential and guiding future research efforts.
The Potential of Epitalon Peptide in Drug Development
Given its diverse range of observed effects, Epitalon-based therapies show promise for various medical conditions, including age-related diseases, inflammatory disorders, and neurodegenerative diseases. Further research is necessary to fully comprehend the mechanisms underlying these effects and to optimize the development of Epitalon-based drugs for clinical use, ultimately enhancing patient outcomes.
Synthesis and Modification of Epitalon Peptide
Ongoing research efforts aim to synthesize and modify Epitalon, creating more potent and stable versions of the peptide. These efforts may lead to the development of novel Epitalon analogues with improved therapeutic properties and reduced side effects, broadening the potential applications of this promising peptide.
Research Applications of Epitalon September 2023
The primary research applications of Epitalon focus on its use in non-human studies across various fields, including ageing, regenerative medicine, and immunology. These studies have provided valuable insights into the potential therapeutic applications of Epitalon and informed the development of novel therapies based on its unique properties.
Future Research Directions for Epitalon
Potential future research directions for Epitalon include exploring new therapeutic applications, further investigation of underlying mechanisms, and the development of optimized Epitalon analogues. These efforts may lead to novel treatments for various medical conditions and contribute to our understanding of the complex processes involved in ageing and disease.
Availability of Epitalon Over the Counter
For those interested in using Epitalon outside of research settings, over-the-counter supplements containing the peptide are available. However, it is essential to consult with a healthcare professional before using any Epitalon product, such as Epitalon pills or nasal spray, to carefully consider the potential risks and benefits associated with supplementation. Always select a reputable supplier to ensure the quality and purity of the product.
Where can I buy Epitalon nasal spray?
Purchasing high-quality Epitalon nasal spray is essential for both research and personal use. To buy Epitalon spray online or find Epitalon spray for sale, it is crucial to source the product from reputable suppliers that ensure high quality, purity, and accurate labelling. Some online retailers specialize in providing research-grade peptides and offer competitive pricing, secure payment options, and fast shipping. By choosing a trusted supplier, you can ensure that you are obtaining a reliable and effective Epitalon product.
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Obtaining Epitalon for Research Purposes can be done through Peptide Sciences, a leading supplier of research-grade peptides. Choosing Peptide Sciences ensures easy and fast ordering, multiple payment options, quantity discounts, free shipping for orders over $200 (USA Only), and a focus on quality, purity, USA-based manufacturing, and exceptional customer service. This ensures researchers have access to high-quality Epitalon for their studies and can rely on a reputable source for their peptide needs.
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Author info: The information provided in this article was taken from studies carried out by recognized researchers, including Anisimov, Vladimir N., and Vladimir Kh. Khavinson, Frolov, D. S., D. A. Sibarov, and A. B. Vol’nova, Khavinson, V., Diomede, F., Mironova, E., Linkova, N., Trofimova, S., Trubiani, O., Sinjari, B., Chalisova, N. I., N. S., Zhekalov, A. O. Orlova, G. A. Ryzhak, Shatilo, and L. V. Magdich.
References:
[i] Anisimov, Vladimir N., and Vladimir Kh. Khavinson. “Peptide Bioregulation of Aging: Results and Prospects.” Biogerontology 11, no. 2 (October 15, 2009): 139–149. doi:10.1007/s10522-009-9249-8.
[ii] Frolov, D. S., D. A. Sibarov, and A. B. Vol’nova. “Altered Spontaneous Electric Activity Detected in Rat Motor Neocortex after Intranasal Epitalon Infusions.” PsycEXTRA Dataset (2004). doi:10.1037/e516032012-081.
[iii] Khavinson, V., Diomede, F., Mironova, E., Linkova, N., Trofimova, S., Trubiani, O., … Sinjari, B. (2020). AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules, 25(3), 609. doi:10.3390/molecules25030609
[iv] Chalisova, N. I., N. S. Linkova, A. N. Zhekalov, A. O. Orlova, G. A. Ryzhak, and V. Kh. Khavinson. “Short Peptides Stimulate Cell Regeneration in Skin During Aging.” Advances in Gerontology 5, no. 3 (July 2015): 176–179. doi:10.1134/s2079057015030054.
[v] Korkushko, O. V., V. Kh. Khavinson, V. B. Shatilo, and L. V. Magdich. “Effect of Peptide Preparation Epithalamin on Circadian Rhythm of Epiphyseal Melatonin-Producing Function in Elderly People.” Bulletin of Experimental Biology and Medicine 137, no. 4 (April 2004): 389–391. doi:10.1023/b:bebm.0000035139.31138.bf.
Vladimir Khavinson is a Professor, Treasurer of the European region of the International Association of Gerontology and Geriatrics; Main gerontologist of the Health Committee of the Government of Saint Petersburg, Russia; Director of the Saint Petersburg Institute of Bioregulation and Gerontology; Vice-president of Gerontological Society of the Russian Academy of Sciences; Head of the Chair of Gerontology and Geriatrics of the North-Western State Medical University, St-Petersburg; Colonel of medical service (USSR, Russia), retired.
Product Usage: THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. This product has not been approved by the FDA for Human Use. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
Unveiling the Intricacies of Epitalon: A Comprehensive Overview
Epitalon, a peptide of significant interest in the scientific community, was first introduced to the world through the pioneering research of Russian scientist Professor Vladimir Khavinson[i]. His relentless pursuit of knowledge has led to a deeper understanding of this peptide and its potential implications in the field of biology and medicine.
Epitalon: A Brief Introduction
Epitalon, often referred to as the “fountain of youth” peptide, is a synthetic tetrapeptide that has been the subject of numerous studies due to its potential health benefits. It is composed of four amino acids: Ala-Glu-Asp-Gly, and its primary function is to stimulate the production of telomerase, a crucial enzyme in our bodies.
The Role of Epitalon in Cellular Health
Telomerase plays a pivotal role in maintaining the health and vitality of our cells. It aids in the replication of telomeres, the protective end caps of our DNA, thereby promoting the growth of new cells and the rejuvenation of old ones. As we age, the production of telomerase decreases, leading to a decline in cell replication and, consequently, the onset of aging-related symptoms.
Epitalon steps in to counteract this decline. By stimulating the production of telomerase, it promotes the replication of telomeres, leading to healthier and more robust cells. Furthermore, Epitalon aids in the production of longer telomeres, which is directly linked to improved cell health and replication.
The Multifaceted Benefits of Epitalon
Epitalon is not just a one-trick pony. Its benefits extend far beyond its role in promoting cellular health. Numerous studies conducted on both animals and humans have indicated that Epitalon is a substance biologically identical to the one produced by the human body, leading to a host of potential health benefits.
Enhanced Melatonin Production
One of the key benefits of Epitalon is its ability to increase melatonin production by the pineal gland. Melatonin is a hormone that regulates sleep-wake cycles and plays a crucial role in maintaining our circadian rhythm. By enhancing melatonin production, Epitalon can potentially improve sleep quality and overall health.
Improved Immune Function
Epitalon has also been shown to improve immunological parameters. By boosting the immune system, it can help the body fight off diseases more effectively.
Anticarcinogenic Effects
Several studies have indicated that Epitalon may have anticarcinogenic effects. While more research is needed to confirm these findings, the potential implications are promising.
Stimulating Antioxidant Defenses
Epitalon can stimulate the body’s antioxidant defenses, helping to protect cells from damage caused by free radicals. This can potentially slow down the aging process and reduce the risk of various diseases.
Restoring Reproductive Function
Epitalon may also play a role in restoring reproductive function. This could have significant implications for individuals struggling with fertility issues.
Increasing Lifespan
Perhaps one of the most exciting potential benefits of Epitalon is its ability to increase lifespan. By lengthening telomeres in human cells, it may potentially extend the human lifespan.
The Future of Epitalon Research
While the potential benefits of Epitalon are promising, it’s important to note that research is ongoing. As scientists continue to unravel the mysteries of this fascinating peptide, we can look forward to gaining a deeper understanding of its potential applications in medicine and health.
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Product Usage: THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. This product has not been approved by the FDA for Human Use. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
