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VIP Peptide Benefits Explained, and Why Researchers Should Be Investigating Vasoactive Intestinal Peptide
VIP, also known as a vasoactive intestinal peptide, is a peptide made of 28 amino acids secreted by cells in the intestinal tract. Research shows that VIP peptide can help reduce inflammation within the animal body and that it is beneficial in treating neurodegenerative disease, inflammatory bowel disease, pulmonary fibrosis, and cardiac fibrosis as research on animals has shown.
Experts say that vasoactive intestinal polypeptide is also a robust immune system regulator, which protects the central nervous system against negative activity. Scientists are also interested in its ability to preserve cognitive function with the onset of neurodegenerative disease.
While this function is not well characterized, studies suggest that some gastrointestinal hormones can function as neurotransmitters in the animal brain. Some of these hormones include glucagon, motilin, somatostatin, and neuropeptide Y.
If you would like to buy VIP peptide for your research project, choose Peptide Sciences. Meanwhile, read on to learn more about how VIP works, its effects on the body, and its side effects.
What is Vasoactive Intestinal Peptide?
VIP belongs to a glucagon superfamily and is produced in several tissues of vertebrates such as the gut, brain, and pancreas. This peptide stimulates contractility in the heart, enhances glycogenolysis, generates vasodilation, lowers blood pressure, and soothes the muscle of the gallbladder and stomach as research on animals has shown.
Decades ago, scientists also learned that VIP hormone increases motility and stimulates water and bile secretion into the pancreatic juice as research on animals has shown.
VIP effects as research on animals have shown, include:
- Digestive system – VIP peptide can induce smooth muscle relaxation, stimulate secretion of water into pancreatic juice, and stimulate inhibition of gastric acid secretion and absorption from the intestinal lumen as research on animals has shown. Scientists also say it can help with digestive conditions like colitis and Crohn’s Disease.
- Heart – the peptide VIP offers significant effects on the cardiovascular system. It stimulates coronary vasodilation and has a positive inotropic and chronotropic effect as tests in animals shows.
- Brain – It can regulate prolactin secretion and stimulate growth hormone secretion in the pituitary gland as research in animals showed.
Let’s find out more about Vasoactive intestinal peptide treatment benefits and how it affects the animal body.
VIP Peptide Benefits
According to researchers, VIP peptide can decrease most inflammatory cytokines as studies in animals showed. Studies in mice[i] also found that the peptide offers potent anti-inflammatory effects on models of arthritis.
Another study discovered that VIP would be needed for immune tolerance, as it can suppress TH1 immune responses while promoting TH2-type reactions. Researchers are currently investigating whether VIP can boost the immune system, decrease TGF-b1 in macrophages, enhance anti-inflammatory response, and inhibit TLR4 activation in the animal body.
Researchers say VIP can improve intestinal barrier homeostasis and lessen inflammation initiated by Th1 cell activity in the onset of inflammatory bowel diseases like Crohn’s and colitis. That’s because vasoactive intestinal peptide can generate T cells that produce interleukin-10 – an inflammation-suppressing peptide. Researchers believe Th1 inflammation plays a significant role in IBD.
By improving intestinal barrier function, scientists can specifically target the cause of inflammatory bowel disease and drastically reduce symptoms in animal test subjects.
VIP offers a three-fold action in the central nervous system: neurotransmitter, neurotrophic/neurogenic, and anti-inflammatory/neuroprotectant. Its journey begins by maintaining barriers in the animal body. Maintaining the blood-brain wall regulates what enters the brain tissue and controls many influences like nutrition, immune function, and oxygenation. When this system is compromised, numerous negative health effects can occur, including stroke, multiple sclerosis, and encephalomyelitis.
Research[ii] shows that VIP peptide hormone can also regulate beta-amyloid accumulation in animals with Alzheimer’s disease. Scientists say it offers potent neuroprotective effects in Parkinson’s disease and other related conditions.
Further evidence suggests that gastrointestinal peptide is a vital neuroprotectant in the brain which can shield it against white matter damage and enhance neuron function. In terms of its effects on PD, VIP provides anti-inflammatory benefits as research in animal bodies shows.
At present, there is no concrete research showing VIP’s role in AD. Some studies show that AD animal test subjects have lower levels of the peptide in their brains, indicating that it could be a potential treatment and preventative. After all, research shows that administration of VIP injection into the brains of mouse models displays a significant reduction in beta-amyloid levels, proving the peptide’s ability to impact the disease positively.
Still, science requires more substantial research and VIP findings before presenting it as a medication for use to the FDA.
VIP Cardiac Fibrosis
Cardiac fibrosis is the end stage of numerous heart conditions. It also leads to a number of serious problems such as valve dysfunction, alterations in cardiac filling, and lessening in contractility. As in the case of lung disease, fibrosis tends to necessitate a transplant in order to remain mortal.
At present, most cardiac research focuses on scar formation, and several drugs can slow the process of cardiac remodelling that causes scarring. However, success rates are low, with animal test subjects experiencing progressive fibrosis and debilitating cardiac function.
According to a recent study on rats, VIP peptide can slow fibrosis down and reverse scarring. Scientists say this is due to the huge reduction in angiotensinogen and angiotensin receptor type 1a expression, which slow down cardiac modelling and fibrosis.
Vasoactive Intestinal Peptide impacts lung function in two different ways. First, it modulates pulmonary vascular remodeling in reaction to inflammation. It does this by suppressing the peptide NFAT – responsible for activating T cells which cause increased inflammation. VIP also controls inflammation in the lungs, preventing many lung-related diseases, including COPD. Therefore, scientists believe that VIP treatment could prevent the end stage of lung disease that can only be cured by transplant.
Second, VIP peptide inhibits the proliferation of smooth muscle cells – a long-term consequence of lung inflammation.
Further evidence suggests that the effects of VIP peptide extend to controlling blood pressure in the pulmonary artery. In turn, this increases cardiac output and improves oxygen capacity.
While research is still new, experts hope that the general public will be able to purchase VIP peptide in the near future for the sake of their health and mortality.
Vasoactive Intestinal Peptide COVID
A recent development from the United States and Switzerland suggests that Aviptadlin (RLF-100) – a synthetic version of VIP – may alleviate lung complications associated with severe cases of COVID-19. Like VIP peptide, Aviptadil inhibits pro-inflammatory cytokine production. Researchers say it may prevent the coronavirus from infecting these cells.
There are currently placebo-controlled trials looking into the effectiveness of VIP therapy and its role in protecting against COVID-19 lung complications.
Participant in a medical study on ventilators given this VIP derivative displayed rapid recovery just three days after the treatment. Even those with severe medical challenges showed positive results.
Recent studies indicate that synthetic versions of VIP show great promise in treating COVID 19. This could be extremely beneficial for VIP treatments as it shows great promise for the peptide – with evidence from successful clinical trials.
VIP Peptide Review 2022
Vasoactive intestinal peptide offers a number of effects in relation to the central nervous system, pulmonary tissue, GI tract, and immune system. Scientists say it also plays an important role in embryonic growth and development.
VIP can help to reduce inflammation in the animal body and treat everything form neurodegenerative disease to cardiac fibrosis – all very serious conditions. So far, studies show how effective this peptide is in preventing morbidity and mortality in animals.
The latest VIP clinical studies show how effective this peptide and its derivatives could be in treating lung-related side effects of COVID-19. Indeed, the research is extremely promising and compelling to many researchers out there.
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Author info: The information provided in this article was taken from studies carried out by recognized researchers including Juarranz, Yasmina, Irene Gutiérrez-Cañas, Begoña Santiago, Mar Carrión, José L. Pablos, and Rosa P. Gomariz, Korkmaz, Orhan Tansel, Hakan Ay, Nurgul Aytan, Isabel Carreras, Neil W. Kowall, Alpaslan Dedeoglu, and Nese Tuncel.
[i] Juarranz, Yasmina, Irene Gutiérrez-Cañas, Begoña Santiago, Mar Carrión, José L. Pablos, and Rosa P. Gomariz. “Differential Expression of Vasoactive Intestinal Peptide and Its Functional Receptors in Humice Osteoarthritic and Rheumatoid Synovial Fibroblasts.” Arthritis & Rheumatism 58, no. 4 (March 27, 2008): 1086–1095. doi:10.1002/art.23403.
[ii] Korkmaz, Orhan Tansel, Hakan Ay, Nurgul Aytan, Isabel Carreras, Neil W. Kowall, Alpaslan Dedeoglu, and Nese Tuncel. “Vasoactive Intestinal Peptide Decreases β-Amyloid Accumulation and Prevents Brain Atrophy in the 5xFAD Mouse Model of Alzheimer’s Disease.” Journal of Molecular Neuroscience 68, no. 3 (November 29, 2018): 389–396. doi:10.1007/s12031-018-1226-8.
VIP Peptides Research Peptides Scientists
Table of Contents
- 1 VIP Peptide Benefits Explained, and Why Researchers Should Be Investigating Vasoactive Intestinal Peptide
- 2 What is Vasoactive Intestinal Peptide?
- 3 VIP effects as research on animals have shown, include:
- 4 VIP Peptide Benefits
- 5 VIP Anti-inflammatory
- 6 VIP Neuroprotectant
- 7 VIP Cardiac Fibrosis
- 8 VIP COPD
- 9 Vasoactive Intestinal Peptide COVID
- 10 VIP Peptide Review 2022
- 11 Buy VIP Peptide
- 12 VIP Peptides Research Peptides Scientists
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December 31, 2020 12:00 AM