CJC 1295 DAC 5mg Uses, Benefits, and Safety
CJC-1295 is a synthetic growth hormone releasing hormone (GHRH) analogue comprising of 30 amino acids[i]. It has a molecular formula C152H252N44O42. In regards to its significant increase in growth hormone secretion, CJC-1295 has been found to be very effective, as research on animals has shown.
CJC-1295 and Ipamorelin are often combined to enhance GHRH.
How Does CJC 1295 Work?
According to scientific studies using animal test subjects, CJC-1295 peptide works by interacting with the growth hormone Insulin-like Growth Factor 1 (IGF-1) as well as Dipeptidyl Amino Peptidase-IV (DPP-IV) enzyme.
What is DPP-IV? DPP-IV is an antigenic enzyme responsible for signal transduction, immune system regulation, and apoptosis. This enzyme has a direct effect on the half-life of GH, reducing it to under 7 minutes.
As per research, CJC-1295 has been shown to minimize the production of DPP-IV, resulting in a feedback loop in which IGF-1 and GH’s half-life is prolonged and will last more than seven days following administration.
What are the Benefits of CJC 1295
There are a number of advantages of CJC-1295 which are being increasingly studied by researchers in the field. Drawing from over a decade of research, the following CJC-1295 benefits have been noted:
- Enhanced growth hormone secretion and IGF-1 levels
- Increased muscle growth
- Improved immune function
- Enhanced body weight through increased protein synthesis
- Increased fat loss
- Improved bone density
- Enhanced cellular repair and regeneration
As CJC-1295 usage is only currently legal for research experimentation, scientists are discovering an increasing amount of new data regarding this research peptide.
Did You Know there are Two Types of CJC 1295?
Growth hormone releasing hormone is produced in the hypothalamus, a small region located at the base of the brain. Its release from the hypothalamus stimulates the release of GH from the pituitary gland. However, this hormone has a very short half-life of just a few minutes, making it less effective.
The first 29 amino acids of the growth hormone are the active segment and called Sermorelin. This peptide was modified to extend its half-life to 30 minutes, making it more effective — known as CJC 1295. Once again, the peptide was modified by adding DAC (Drug Affinity Complex) to it, increasing its half-life to 8 days.
You can buy CJC-1295 + DAC or just CJC-1295 pure.
What is CJC 1295 DAC?
Or what is DAC for starters?
DAC stands for drug affinity complex and is considered by researchers to result in greater peptide bonding.
The main purpose of DAC is that it extends the half-life of CJC 1295 peptide.
According to recent studies[ii], when you combine CJC 1295 with DAC, the half-life extends to nearly 8 days — a huge jump from the regular half-life of 30 minutes.
The shorter the half-life, the lesser the effects. That is why combining CJC 1295 and DAC promotes more effective results than CJC-1295 without DAC.
Benefits of CJC 1295 with DAC
Recent scientific studies show that testing conducted on animals prove CJC 1295 with DAC promotes the following:
- Heightened protein synthesis
- Greater ingestion of protein
- An increase in bone density
- Enhanced muscle growth
- Faster recovery time
The above benefits will naturally occur in animals with CJC 1295 with or without DAC. Still, scientists believe that DAC enhances the results of using CJC 1295 on its own. Therefore, it is recommended to use DAC with CJC-1295 for your research.
What are the Effects of CJC 1295?
According to new studies[iii], CJC-1295 peptide has shown to significantly increase growth hormone and IGF-1’s half-life which results in more powerful effects. Let’s take a look at the top CJC-1295 results, as confirmed by scientific researchers.
Increased Protein Synthesis
Studies show that CjC1295 can increase the rate of protein synthesis in animal subjects, which results in dramatic growth in their muscle size and mass over time. This suggests CJC 1295 for muscle growth is an effective treatment, as proven in studies on animals.
Boosted Bone Density
Thanks to the increase in protein synthesis, CJC 1295 also plays a role in increasing bone density. As per research, animal subjects have demonstrated a higher mineral matter per square centimeter in their bones following the intake of CJC-1295.
According to studies, CJC 1295 improves sleep. Not just sleep but the quality of sleep. When testing the measure of quality sleep in animal subjects, research shows that the increased rate of protein synthesis is compensated by the increased amount of deep sleep.
Reduced Body Fat
Research suggests that CJC 1295 fat loss effects are profound. Due to CJC 1295’s effect on DPP-IV and GHRH, it plays a vital role in lipolysis, otherwise known as the reduction of body fat. It has additionally been found to heighten lipolysis in animal subjects, thus reducing their total body fat.
Is CJC 1295 Safe?
Scientists consider CJC 1295 to be a safe product. Currently, CJC 1295 is only allowed to be used for research purposes. Human usage is prohibited.
Studies show from CJC 1295 peptide research that the peptide could result in GH resistance developing. This is why it is best to provide breaks between administrations so that resistance doesn’t develop in your research.
Side effects of CJC-1295 may include headache, diarrhea, vasodilation, nausea and abdominal pain, as confirmed by researchers who have tested CJC-1295 on animal subjects.
Advantages of CJC-1295 DAC
CJC-1295 DAC is a synthetic analog of growth hormone-releasing hormone (GHRH) that exhibits several advantages over traditional GHRH analogs:
- Extended half-life: The addition of the Drug Affinity Complex (DAC) significantly prolongs the half-life of CJC-1295, allowing for less frequent administration and more stable plasma levels.
- Enhanced potency: CJC-1295 DAC demonstrates a higher binding affinity for GHRH receptors, resulting in increased potency and efficacy.
- Improved stability: The DAC modification enhances the stability of CJC-1295, making it more resistant to degradation and maintaining its activity longer.
CJC-1295 DAC Research Topics June 2023
The Efficacy of CJC-1295 DAC in Treating Specific Conditions
Although the use of CJC-1295 DAC in humans is beyond the scope of this article, non-human studies have demonstrated its potential in addressing several conditions, such as:
- GH deficiency
- Age-related muscle wasting
- Obesity and metabolic disorders
- Impaired wound healing
The Role of CJC-1295 DAC in Cellular and Molecular Biology Research
CJC-1295 DAC has proven valuable in the study of various cellular and molecular processes, including:
- Signal transduction pathways
- Gene expression regulation
- Cellular proliferation and differentiation
- Protein synthesis and degradation
- Apoptosis and cell survival
The Potential of CJC-1295 DAC in Drug Development
The unique properties of CJC-1295 DAC make it an attractive candidate for the development of new drugs targeting:
- GH and IGF-1 deficiencies
- Metabolic disorders
- Age-related degenerative conditions
- Wound healing and tissue repair
The Synthesis and Modification of CJC-1295 DAC
CJC-1295 DAC is synthesized using solid-phase peptide synthesis (SPPS) techniques, followed by the addition of the DAC moiety through a bioconjugation process. This modification not only enhances the peptide’s stability and half-life but also improves its overall efficacy.
How to Store CJC-1295 DAC
Proper storage of CJC-1295 DAC is crucial to maintaining its integrity and effectiveness. The peptide should be stored as a lyophilized powder at -20°C, protected from light and moisture. Once reconstituted, it should be kept at 2-8°C and used within a few weeks. To prevent degradation, avoid multiple freeze-thaw cycles and store reconstituted solutions in aliquots.
Future Research Directions for CJC-1295 DAC
As our understanding of the CJC-1295 DAC peptide continues to grow, several exciting avenues for future research have emerged:
- Further elucidation of the molecular mechanisms underlying CJC-1295 DAC’s effects on GH and IGF-1 regulation.
- Investigation of potential synergistic effects when combined with other growth factors, hormones, or peptides.
- Exploration of its potential in combating age-related cognitive decline and neurodegenerative diseases in non-human models.
- Evaluation of the therapeutic potential of CJC-1295 DAC in veterinary medicine, particularly for growth promotion and tissue repair in animals.
- Development of novel drug delivery systems to optimize the administration and effectiveness of CJC-1295 DAC.
In conclusion, the CJC-1295 DAC peptide has shown great promise in various non-human research applications. Further studies are needed to uncover its full potential and possible applications in drug development, cellular and molecular biology, and veterinary medicine. As our knowledge of this peptide expands, so too does the potential for scientific breakthroughs and advancements in the understanding and treatment of numerous conditions.
Buy CJC 1295 With DAC Peptide Sciences 2023
When buying peptides, it is always best to purchase from a recognized company or authorized doctor, in order to receive the best quality CJC 1295 online. Which company is considered the best CJC 1295 supplier 2023?
Peptide Sciences is founded by Dr Logan., M.D. who holds a doctorate degree from Case Western Reserve University School of Medicine as well as a B.S. in Molecular Biology.
You can buy CJC 1295 DAC 2mg for just $53.00.
Order now to get the highest quality, US-manufactured CJC 1295 with DAC.
Author info and References
Author info: The information provided in this article was taken from studies carried out by recognized researchers, including Teichmice SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohmice LA., Rohit Chaudhary RPh, Benquet C, Pham K, and Robitaille M.
[i] “Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults,” Teichmice SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohmice LA. The Journal of Clinical Endocrinology & Metabolism, 91(3), 799–805. doi: http://dx.doi.org/10.1210/jc.2005-1536
[ii] “Should you use CJC 1295 with DAC or without?” Rohit Chaudhary RPh: https://riteawaypharmacyrx.com/cjc-1295-with-or-without-dac/
[iii] “CJC-1295 (DAC-GRF), a long acting GRF analog, enhances pulsatile GH secretion, increases IGF-I levels, and restores linear growth.” Benquet C, Castaigne J-P, Pham K, Robitaille M, Frohmice LA. Program of the 86th Annual Meeting of The Endocrine Society, New Orleans, LA.
- Sam Teichman MD, FACC, FESC, FACP CJC-1295
Global corporate and drug development strategic and operational experience in multiple therapeutic areas including cardiovascular, endocrinology, gastroenterology.
Sam Teichman has a MD, FACC, FESC, FACP from the Columbia University College of Physicians & Surgeons. Sam Teichman MD, FACC, FESC, FACP currently works at the Consultant: Interim CMO and has 9 years experience in researching Multiple therapeutic areas including cardiovascular, endocrinology, gastroenterology at the Columbia University College of Physicians & Surgeons. One of their notable works include Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.. Published online Mar. 2006. doi:http://dx.doi.org/10.1210/jc.2005-1536 [PubMed]
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Product Usage: THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. This product has not been approved by the FDA for Human Use. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.