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Signs of Melanocyte-stimulating Hormone Deficiency
A deficiency in melanocyte-stimulating hormone results in a loss of natural protection from UV rays and a lack of skin pigmentation. A sufficiency can also increase inflammation, pain, urination, thirst, and cause sleep issues. Research also shows that an MSH deficiency can also result in increased food intake, weight gain, and obesity.
Effects of High Levels of MSH
According to research, there is a direct link between high levels of melanocyte-stimulating hormone and increased melanin production. This is normally the result of prolonger sun exposure and skin tanning.
Those with high blood level of alpha-MSH hormone generally do not tan well or have skin pigmentation, while fair-skinned people produce less melanin due to their fluctuations in MSH hormone receptors. Thus, they do not respond to melanocyte-stimulating treatment.
Melanocytes Research 2020
Extensive research is being carried out on pigmentation disorders using melanocyte models. So far, the research looks impressive and demonstrates how effective melanocyte-stimulating peptides are for tanning the skin, promoting weight loss, and treating pigmentation disorders.
While it is not FDA approved yet, with further research, scientists hope it will be available to the public as a treatment for medical conditions.
[i] Dorr, Robert T., Ruskin Lines, Norman Levine, Christine Brooks, Li Xiang, Victor J. Hruby, and Mac E. Hadley. “Evaluation of Melanotan-II, a Superpotent Cyclic Melanotropic Peptide in a Pilot Phase-I Clinical Study.” Life Sciences 58, no. 20 (April 1996): 1777–1784. doi:10.1016/0024-3205(96)00160-9.
[ii] Dong, Liang et al. “Melanocyte-stimulating hormone directly enhances UV-Induced DNA repair in keratinocytes by a xeroderma pigmentosum group A-dependent mechanism.” Cancer research vol. 70,9 (2010): 3547-56. doi:10.1158/0008-5472.CAN-09-4596
Melanocyte-stimulating Hormone Research Peptides Scientists