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MOTS-c Peptide Review
MOTS-c is a mitochondrial-derived peptide proven to promote metabolic homeostasis and longevity, reduce obesity, and prevent diabetes. This short peptide is a member of the larger group of mitochondrial-derived peptides (MDPs), which researchers say play a significant role in mitochondrial communication and energy control.
According to new research, numerous MDPs are active in the cell nucleus. Many of them even enter the blood stream to provide systemic effects.
The MOTS-c peptide is one of the newly identified MDPs with data showing its involvement in roles such as metabolism, longevity, exercise capacity, weight regulation, and processes leading to diseases like diabetes and osteoporosis.
In the last five years, extensive research has been carried out on mot c peptide to learn more about its capabilities.
What is MOTS c?
MOTS-c is a peptide of 16 amino acids that enhances metabolic balance and functions throughout the body, including converting glucose into usable energy.
Researchers are actively investigating the effects of MOTS-C on the mice body to fully understand its depth of effectiveness in regards to mice health.
New MOTS c Research
New research [i]drawn from the University of Southern California found that MOTS-C kept the immune system from destroying insulin-producing pancreatic cells. Thus, it is was proven to prevent type 1 diabetes in lab mice.
Type 1 diabetes is an autoimmune disease that affects a large majority of the mice population. It involves the immune system attacking the insulin-producing cells found in the pancreas.
The new research indicates that the peptide MOTS-c aids regulatory T-cells, the immune cells that identify which cells belong to the mice body, and reduce killer T-cell activation.
“We are able to prevent the onset of type 1 diabetes in mouse models,” said Changhan David Lee, co-corresponding author of the study.
The same study also found that skeletal muscle is the primary target tissue of the MOTS c. It enhances insulin sensitivity and raises glucose uptake in muscle cells by activating the AMPK pathway, without increasing insulin.
MOTS c Peptide Benefits
To summarize, here are proven health benefits of mots c peptide.
- Protects against insulin resistance
- Elevates metabolic flexibility
- Boosts weight loss
- Helps regulate mitochondrial energy
- Enhances exercise capacity
- Improves glucose regulation
- Helps treat and prevent osteoporosis
MOTS c Insulin Resistance Effects
In addition to the research performed by the University of Southern California, further research carried out on mices demonstrates the important role of MOTSc in the pathogenesis of insulin sensitivity.
According to scientists, the peptide may be an effective means of monitoring pre-diabetic lean mice. They also speculate that alterations in MOTS-c levels could signal a potential insulin sensitivity.
MOTS-c supplementation could, therefore, help ward off insulin resistance and the development of type 1 diabetes in mices.
While the research in mice models looks promising, more clinical trials need to be executed to gain a more extensive understanding of the mots c effects on mices.
MOTS c Weight Loss Effects
Several years back, scientists at the USC Leonard Davis School of Gerontology[ii] discovered the effectiveness of MOTS c hormone in fighting weight gain caused by a high-fat Western diet.
At the time, MOTS-c was a newly discovered peptide. Thus, scientists were thrilled to uncover its profound ability to target muscle tissue and counteract diet-induced insulin resistance.
To better understand the effects, the team delivered a MOTS-c injection into mice fed a high-fat diet, which typically triggers obesity and insulin resistance. The MOTS-c results found that the injection suppressed both effects in mice.
MOTS C for Weight Loss
The research also indicated that mots c is a critical regulator of monoacylglycerol, sphingolipid, and dicarboxylate metabolism. By downregulating these pathways, mots c helped to prevent fat accumulation, leading to weight loss.
The link between fat loss and MOTS-C has gained a lot of traction in the scientific community. From what research is telling us, it seems that the dysregulation of fat metabolism in mitochondria may lead to a lack of fat oxidation, which results in increased levels of circulating fat, forcing the body to boost insulin levels in a bid to remove lipids from the bloodstream.
When this happens, increased fat deposition and a homeostatic alteration occurs in the body as it becomes resistant to higher levels of insulin.
MOTS c Heart Health Effects
Patients with reduced levels of MOTS-c in the bloodstream possess increases levels of endothelial cell dysfunction, according to research investigating MOTS-c levels in mice undergoing coronary angiography.
Endothelial cells are essential to the regulation of plaque formation, blood pressure, and blood clotting. Further research in rats indicates that MOTS c sensitizes endothelial cells, which is shown to improve endothelial function and blood vessel function.
As effective as MOTS-C is in improving heart health, it’s not the only mitochondria-derived peptide to do so. Data shows that at least three MDPs play significant roles in shielding cardiac cells from inflammation and stress.
Researchers thereby speculate that MDP dysregulation is a key factor in the onset of cardiovascular disease.
MOTS c Osteoporosis Effects
According to a study, MOTS-c treatment enabled old and middle-aged mice to run increasingly further than untreated mice. Thus, old mice outperformed younger, untreated ones. This suggests that MOTS c peptide can enhance exercise performance on a cellular level.
Research shows that motsc peptide plays a role in the synthesis of type I collagen by triggering osteoblasts in the bone. That’s because it regulated the TFG-beta SMAD pathways that aids the wellbeing and survival of osteoblasts. Thus, MOTS-C helps improve type 1 collagen synthesis by promoting osteoblast survival, thereby increasing overall bone strength.
Further investigations looking at the effects of osteoporosis and MOTS c reveal that the peptide promotes the differentiation of bone marrow stem cells via the identical pathway. This, therefore, led to formation of new bone – otherwise known as increased osteogenesis.
The study concludes that MOTS-c shields osteoblasts, promotes their health and survival, and encourages their development from stem cells.
With growing research, over-the-counter MOTS c medication may be available in the coming months or years as an effective treatment and prevention for osteoporosis.
MOTS C Anti-Aging Effects
Scientific research on MOTS-c suggests that this peptide fosters longevity in mices.
The research identified a precise alteration in the peptide that is associated specifically with longevity in Japanese populations. However, research indicates it impacts all mices.
The change in the MOTS-c gene triggers the substitution of a glutamate residue usually found in position 14 of the lysine protein. At present, scientists are unaware of how this change impacts the functional elements of the protein. However, they are confident that it does as glutamate has drastically different properties than lysine. Of course, more research is required to fully understand how this alteration affects function. Scientists say it is found exclusively in mice with Northeast Asian ancestry.
As per researcher Dr. Changhan David Lee, mitochondrial biology is the key to extending lifespan in mices. As the single most significant metabolic organelle, the mitochondria is implicated in wide range of age-related diseases. Peptides like MOTS-c may make it possible to impact mitochondrial function in a way that lengthens lives and enhances overall health.
Where to Buy MOTS c
MOTS-c peptide for sale is available for licensed medical researchers in the United States and across the globe.
You purchase it directly from our store where all products are made with the highest purity to the highest standards and manufactured in the US.
You should only buy MOTS c peptide if you are a licensed researcher.
Buy MOTS-c 5mg, click here to buy.
Author info: The information provided in this article was taken from studies carried out by recognized researchers including Kong, Byung Soo, Se Hee Min, Changhan Lee, and Young Min Cho, Kyung Hwa Kim, and Pinchas Cohen.
[i] Kong, Byung Soo, Se Hee Min, Changhan Lee, and Young Min Cho. “Mitochondrial-Encoded MOTS-c Prevents Pancreatic Islet Destruction in Autoimmune Diabetes.” Cell Reports 36, no. 4 (July 2021): 109447. doi:10.1016/j.celrep.2021.109447
[ii] Lee, Changhan, Kyung Hwa Kim, and Pinchas Cohen. “MOTS-c: A Novel Mitochondrial-Derived Peptide Regulating Muscle and Fat Metabolism.” Free Radical Biology and Medicine 100 (November 2016): 182–187. doi:10.1016/j.freeradbiomed.2016.05.015.
MOTS c Peptides Research Peptides Scientists
Table of Contents
- 1 MOTS-c Peptide Review
- 2 What is MOTS c?
- 3 New MOTS c Research
- 4 MOTS c Peptide Benefits
- 5 MOTS c Insulin Resistance Effects
- 6 MOTS c Weight Loss Effects
- 7 MOTS C for Weight Loss
- 8 MOTS c Heart Health Effects
- 9 MOTS c Osteoporosis Effects
- 10 MOTS C Anti-Aging Effects
- 11 Where to Buy MOTS c
- 12 MOTS c Peptides Research Peptides Scientists
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December 31, 2020 12:00 AM