MOTS-c 5mg


Availability: In stock Manufactured in USA

Purity: 99%

Buy MOTS c Peptide

MOTS-c is a mitochondrial-derived peptide proven to prevent diabetes, as research on animals has shown. Buy MOTS-c today. Get the best price for MOTS c for sale.
Buy MOTS-c
MOTS-c 5mg
$60.00 Buy Now

Availability: In stock Manufactured in USA

99% Purity

FREE Shipping for orders over $200 (USA Only)

$15.00 Flat Rate Shipping Worldwide (Most Countries)

*Includes one 30mL Bacteriostatic Water with orders over $300.00


Last updated on March 4, 2022

Product Description

MOTS-c Peptide Review

MOTS-c is a mitochondrial-derived peptide proven to promote metabolic homeostasis and longevity, reduce obesity, and prevent diabetes as research on animal test subjects has shown. This short peptide is a member of the larger group of mitochondrial-derived peptides (MDPs), which researchers say play a significant role in mitochondrial communication and energy control.

According to new research, numerous MDPs are active in the cell nucleus. Many of them even enter the blood stream to provide systemic effects as tests in animal test subjects have shown.

The MOTS-c peptide is one of the newly identified MDPs with data showing its involvement in roles such as metabolism, longevity, exercise capacity, weight regulation, and processes leading to diseases like diabetes and osteoporosis as research on animal test subjects have shown.

In the last five years, extensive research has been carried out on mot c peptide to learn more about its capabilities.

What is MOTS c?

MOTS-c is a peptide of 16 amino acids that enhances metabolic balance and functions throughout the animal test subjects’ bodies, including converting glucose into usable energy.

Researchers are actively investigating the effects of MOTS-C on the animal test subjects’ bodies to fully understand its depth of effectiveness on the animal test subjects’ bodies.

New MOTS c Research

New research [i]drawn from the University of Southern California found that MOTS-C kept the immune system from destroying insulin-producing pancreatic cells. Thus, it is was proven to prevent type 1 diabetes in lab mice.

Type 1 diabetes is an autoimmune disease that affects a large group. It involves the immune system attacking the insulin-producing cells found in the pancreas.

The new research indicates that the peptide MOTS-c aids regulatory T-cells, the immune cells that identify which cells belong to the animal test subjects’ bodies and reduce killer T-cell activation.

“We are able to prevent the onset of type 1 diabetes in mouse models,” said Changhan David Lee, co-corresponding author of the study.

The same study also found that skeletal muscle is the primary target tissue of the MOTS c. It enhances insulin sensitivity and raises glucose uptake in muscle cells by activating the AMPK pathway, without increasing insulin in the animal test subjects’ bodies.

MOTS c Peptide Benefits

To summarize, here are proven health benefits of mots c peptide as research in animals has shown:

  • Protects against insulin resistance
  • Elevates metabolic flexibility
  • Boosts weight loss
  • Helps regulate mitochondrial energy
  • Enhances exercise capacity
  • Improves glucose regulation
  • Helps treat and prevent osteoporosis

MOTS c Insulin Resistance Effects

In addition to the research performed by the University of Southern California, further research carried out on mice demonstrates the important role of MOTSc in the pathogenesis of insulin sensitivity.

According to scientists, the peptide may be an effective means of monitoring pre-diabetic lean mice. They also speculate that alterations in MOTS-c levels could signal a potential insulin sensitivity.

While the research in animal models looks promising, more clinical trials need to be executed to gain a more extensive understanding of the mots c effects.

MOTS c Weight Loss Effects

Several years back, scientists at the USC Leonard Davis School of Gerontology[ii] discovered the effectiveness of MOTS c hormone in fighting weight gain caused by a high-fat Western diet.

At the time, MOTS-c was a newly discovered peptide. Thus, scientists were thrilled to uncover its profound ability to target muscle tissue and counteract diet-induced insulin resistance in animal test subjects.

To better understand the effects, the team delivered a MOTS-c injection into mice fed a high-fat diet, which typically triggers obesity and insulin resistance. The MOTS-c results found that the injection suppressed both effects in mice.

MOTS C for Weight Loss

The research also indicated that mots c is a critical regulator of monoacylglycerol, sphingolipid, and dicarboxylate metabolism. By downregulating these pathways, mots c helped to prevent fat accumulation, leading to weight loss in the animal test subjects.

The link between fat loss and MOTS-C has gained a lot of traction in the scientific community. From what research is telling us, it seems that the dysregulation of fat metabolism in mitochondria may lead to a lack of fat oxidation, which results in increased levels of circulating fat, forcing the animal body to boost insulin levels in a bid to remove lipids from the bloodstream.

When this happens, increased fat deposition and a homeostatic alteration occurs in the animal body as it becomes resistant to higher levels of insulin.

MOTS c Heart Health Effects

With reduced levels of MOTS-c in the bloodstream possess increases levels of endothelial cell dysfunction, according to research investigating MOTS-c levels in animal test subjects undergoing coronary angiography.

Endothelial cells are essential to the regulation of plaque formation, blood pressure, and blood clotting. Further research in rats indicates that MOTS c sensitizes endothelial cells, which is shown to improve endothelial function and blood vessel function.

As effective as MOTS-C is in improving heart health, it’s not the only mitochondria-derived peptide to do so. Data shows that at least three MDPs play significant roles in shielding cardiac cells from inflammation and stress.

Researchers thereby speculate that MDP dysregulation is a key factor in the onset of cardiovascular disease.

MOTS c Osteoporosis Effects

According to a study, MOTS-c treatment enabled old and middle-aged mice to run increasingly further than untreated mice. Thus, old mice outperformed younger, untreated ones. This suggests that MOTS c peptide can enhance exercise performance on a cellular level.

Research shows that motsc peptide plays a role in the synthesis of type I collagen by triggering osteoblasts in the bone of the animal test subjects. That’s because it regulated the TFG-beta SMAD pathways that aids the wellbeing and survival of osteoblasts. Thus, MOTS-C helps improve type 1 collagen synthesis by promoting osteoblast survival, thereby increasing overall bone strength.

Further investigations looking at the effects of osteoporosis and MOTS c reveal that the peptide promotes the differentiation of bone marrow stem cells via the identical pathway. This, therefore, led to formation of new bone – otherwise known as increased osteogenesis.

The study concludes that MOTS-c shields osteoblasts, promotes their health and survival, and encourages their development from stem cells as research on animal test subjects has shown.

With growing research, over-the-counter MOTS c medication may be available in the coming months or years as an effective treatment and prevention for osteoporosis.

MOTS C Anti-Aging Effects

Scientific research on MOTS-c suggests that this peptide fosters longevity in animal test subjects.

The research identified a precise alteration in the peptide that is associated specifically with longevity in animal test subjects. However, research indicates it impacts all animals.

The change in the MOTS-c gene triggers the substitution of a glutamate residue usually found in position 14 of the lysine protein. At present, scientists are unaware of how this change impacts the functional elements of the protein in animal bodies. However, they are confident that it does as glutamate has drastically different properties than lysine. Of course, more research is required to fully understand how this alteration affects function.

As per researcher Dr. Changhan David Lee, mitochondrial biology is the key to extending lifespan in animal test subjects. As the single most significant metabolic organelle, the mitochondria are implicated in wide range of age-related diseases. Peptides like MOTS-c may make it possible to impact mitochondrial function in a way that lengthens lives and enhances overall health from animal test subjects.

Where to Buy MOTS c

MOTS-c peptide for sale is available for licensed medical researchers in the United States and across the globe.

You purchase it directly from our store where all products are made with the highest purity to the highest standards and manufactured in the US.

You should only buy MOTS c peptide if you are a licensed researcher.

Buy MOTS-c 5mg, click here to buy.


Author info: The information provided in this article was taken from studies carried out by recognized researchers including Kong, Byung Soo, Se Hee Min, Changhan Lee, and Young Min Cho, Kyung Hwa Kim, and Pinchas Cohen.



[i] Kong, Byung Soo, Se Hee Min, Changhan Lee, and Young Min Cho. “Mitochondrial-Encoded MOTS-c Prevents Pancreatic Islet Destruction in Autoimmune Diabetes.” Cell Reports 36, no. 4 (July 2021): 109447. doi:10.1016/j.celrep.2021.109447

[ii] Lee, Changhan, Kyung Hwa Kim, and Pinchas Cohen. “MOTS-c: A Novel Mitochondrial-Derived Peptide Regulating Muscle and Fat Metabolism.” Free Radical Biology and Medicine 100 (November 2016): 182–187. doi:10.1016/j.freeradbiomed.2016.05.015.


Cite this article as: Research Peptides Scientist, "MOTS-c 5mg," in, March 4, 2022, Accessed May 31, 2023.


MOTS c Peptides Research Peptides Scientists

Product Usage: THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. This product has not been approved by the FDA for Human Use. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.


Product Brand:











In stock

Product Price:



Buy 5 for $57.00 each and save 5%, Buy 10 for $55.00 each and save 9%

Shipping USA:

FREE Shipping for orders over $200 (USA Only)

Shipping Worldwide:

$15.00 Flat Rate Shipping Worldwide (Most Countries)


*Includes one 30mL Bacteriostatic Water with orders over $300.00

Price Valid Until:

December 31, 2020 12:00 AM