Pentapeptide-18 (Leuphasyl) 200mg (Topical)


Availability: In stockManufactured in USA

Purity: 99%

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Revitalize your skin with Pentapeptide-18 (Leuphasyl) (Topical) – a powerful anti-aging solution for a smoother, more youthful complexion.

Pentapeptide-18 (Leuphasyl) is a synthetic peptide used in skincare products for its potential anti-aging effects. It has been extensively studied for its ability to reduce the appearance of wrinkles and fine lines caused by repetitive facial expressions.

By targeting specific pathways involved in muscle movement and neurotransmission, this peptide helps relax facial muscles and minimize the formation of expression lines. Pentapeptide-18 works by interfering with the communication between nerves and muscles, leading to a decrease in dynamic wrinkles and potentially improving skin texture. Further research is needed to fully understand its effects.

Pentapeptide-18 (Leuphasyl) 200mg (Topical) for Sale
Pentapeptide-18 (Leuphasyl) 200mg (Topical)
$230.00 Buy Now

Availability: In stockManufactured in USA

Purity: 99%

FREE Shipping for orders over $200 (USA Only)

$15.00 Flat Rate Shipping Worldwide (Most Countries)

*Includes one 30mL Bacteriostatic Water with orders over $300.00


Last updated on November 5, 2023

Unlocking the Power of Pentapeptide-18 (Leuphasyl): Revolutionary Topical Solution for Youthful Skin

Introducing Pentapeptide-18 (Leuphasyl) (Topical): the groundbreaking research product that promises to revolutionize skincare. Backed by extensive studies, this potent formula has shown remarkable results in reducing the appearance of wrinkles and fine lines. With its unique properties, Pentapeptide-18 offers a safe and effective solution for youthful-looking skin. Experience the transformative power of science with this remarkable topical treatment.

1. What is Pentapeptide-18 (Leuphasyl) (Topical)?

Pentapeptide-18, also known as Leuphasyl, is a synthetic peptide that belongs to the family of neuropeptides. It is commonly used in skincare products for its potential anti-aging effects. Pentapeptide-18 has been extensively studied for its ability to reduce the appearance of wrinkles and fine lines, particularly those caused by repetitive facial expressions.

In non-human research studies, Pentapeptide-18 has shown promising results in inhibiting muscle contractions and reducing neurotransmitter release. By targeting specific pathways involved in muscle movement and neurotransmission, this peptide may help relax facial muscles and minimize the formation of expression lines.

It is important to note that Pentapeptide-18 (Leuphasyl) is primarily used in topical formulations for cosmetic purposes and should not be confused with its injectable form, which may have different applications.

2. How Does Pentapeptide-18 (Leuphasyl) (Topical) Work?

Pentapeptide-18 (Leuphasyl) works by interfering with the communication between nerves and muscles in the skin. It specifically targets the SNARE complex, a protein complex involved in neurotransmitter release at the neuromuscular junction. By inhibiting the release of acetylcholine, a neurotransmitter responsible for muscle contraction, Pentapeptide-18 helps to relax facial muscles and reduce their repetitive movements.

The reduction in muscle contractions can lead to a decrease in dynamic wrinkles caused by these movements, such as crow’s feet or frown lines. Additionally, by modulating neurotransmitter release, Pentapeptide-18 may also contribute to a smoother complexion and improved skin texture.

It is worth mentioning that the exact mechanism of action of Pentapeptide-18 is still being studied, and further research is needed to fully understand its effects on muscle contractions and neurotransmission.

3. Pentapeptide-18 (Leuphasyl) (Topical) Benefits

The potential benefits of Pentapeptide-18 (Leuphasyl) observed in non-human research studies are primarily related to its anti-aging properties. Some of the key benefits include:

  • Reduction in the appearance of wrinkles and fine lines caused by repetitive facial expressions
  • Relaxation of facial muscles, leading to a more youthful and relaxed appearance
  • Improvement in overall skin texture and smoothness
  • Potential prevention of new wrinkle formation

These benefits make Pentapeptide-18 an attractive ingredient for skincare products targeting age-related concerns, particularly those associated with facial expression lines.

4. Pentapeptide-18 (Leuphasyl) (Topical) Side Effects

In non-human studies, no significant side effects have been reported with the topical use of Pentapeptide-18 (Leuphasyl). However, it is important to note that individual responses may vary, and human studies are limited.

As with any skincare product or cosmetic ingredient, it is recommended to perform a patch test before applying Pentapeptide-18 topically to ensure there are no adverse reactions or allergies. If any irritation or discomfort occurs, it is advisable to discontinue use and consult a healthcare professional.

Overall, based on current research, Pentapeptide-18 (Leuphasyl) appears to have a favorable safety profile for topical use. However, further studies are needed to fully evaluate its long-term effects and potential interactions with other skincare ingredients.

5. Advantages of Pentapeptide-18 (Leuphasyl) (Topical)

Pentapeptide-18 (Leuphasyl) offers several advantages compared to other anti-aging treatments:

  • Targeted Approach: This peptide specifically targets muscle contractions and neurotransmitter release involved in facial expression lines, making it suitable for addressing dynamic wrinkles caused by repetitive movements.
  • Non-Invasive: Unlike injectable treatments like Botox, Pentapeptide-18 is applied topically, eliminating the need for injections or invasive procedures.
  • Complementary Effects: Pentapeptide-18 can be used alongside other skincare products or treatments to enhance their overall anti-aging effects.
  • Potential Preventative Effects: By reducing muscle contractions and minimizing the formation of new wrinkles, Pentapeptide-18 may have a preventive role in maintaining youthful skin.

These advantages make Pentapeptide-18 a popular choice among individuals seeking non-invasive solutions for reducing the appearance of wrinkles and fine lines.

6. Pentapeptide-18 (Leuphasyl) (Topical) Research Topics

The research involving Pentapeptide-18 covers various areas related to its efficacy, formulation, dosage, and application methods. Some key research topics include:

  • Optimal Dosage: Determining the most effective concentration of Pentapeptide-18 in topical formulations for maximum anti-aging benefits.
  • Formulation Development: Exploring different formulations and delivery systems to enhance the stability, penetration, and bioavailability of Pentapeptide-18 in skincare products.
  • Combination Therapy: Investigating the synergistic effects of Pentapeptide-18 when used in combination with other anti-aging ingredients or treatments.
  • Long-term Effects: Assessing the long-term safety and efficacy of Pentapeptide-18 for prolonged use in skincare regimens.

By addressing these research topics, scientists aim to further optimize the use of Pentapeptide-18 in skincare formulations and expand our understanding of its potential benefits.

7. Future Research Directions for Pentapeptide-18 (Leuphasyl) (Topical)

Future research on Pentapeptide-18 (Leuphasyl) is expected to focus on several areas that require further investigation:

  • Clinical Studies: Conducting well-controlled clinical trials involving human participants to evaluate the efficacy and safety of Pentapeptide-18 in real-world settings.
  • Mechanism Elucidation: Expanding our understanding of the precise mechanisms through which Pentapeptide-18 affects muscle contractions and neurotransmission at a molecular level.
  • Optimized Formulations: Developing advanced formulations that enhance the stability, bioavailability, and skin penetration of Pentapeptide-18 for improved anti-aging effects.
  • Comparative Studies: Comparing the efficacy and safety profiles of Pentapeptide-18 with other commonly used anti-wrinkle treatments to establish its position within the market.

These future research directions will contribute to a more comprehensive understanding of Pentapeptide-18 and its potential applications in the field of dermatology and cosmetic science.

8. Pentapeptide-18 (Leuphasyl) (Topical) Before and After in Research

In non-human research studies, visual evidence showcasing the effects of Pentapeptide-18 before and after treatment has been observed. These studies typically involve the application of topical formulations containing different concentrations of Pentapeptide-18 on animal models or skin samples.

The before and after images often demonstrate a reduction in the depth and severity of wrinkles, particularly those associated with facial expression lines. The treated areas appear smoother, with fewer visible lines and improved overall skin texture.

It is important to note that individual results may vary, and human studies are necessary to validate these findings. However, the before and after images from non-human research provide valuable insights into the potential efficacy of Pentapeptide-18 in reducing the signs of aging.

9. Pentapeptide-18 (Leuphasyl) (Topical) Cycle for Research

The recommended cycle duration for conducting non-human research with Pentapeptide-18 (Leuphasyl) varies depending on the specific study design and objectives. However, typical research cycles involving this peptide range from a few weeks to several months.

The frequency of application may also vary but is usually once or twice daily for topical formulations. Researchers may choose to assess different dosages or concentrations of Pentapeptide-18 within a single cycle to evaluate their effects on wrinkle reduction or other desired outcomes.

It is important to follow ethical guidelines for animal research or use approved skin models when conducting studies with Pentapeptide-18 to ensure humane treatment and accurate representation of the peptide’s effects.

10. Best Pentapeptide-18 (Leuphasyl) (Topical) Results in Research

The most significant findings from non-human studies using Pentapeptide-18 (Leuphasyl) include:

  • Visible Reduction in Wrinkles: Pentapeptide-18 has consistently shown a reduction in the depth and severity of wrinkles, particularly those caused by repetitive facial expressions.
  • Smoother Skin Texture: The application of Pentapeptide-18 has been associated with improved overall skin texture, resulting in a more youthful and radiant appearance.
  • Long-lasting Effects: Some studies suggest that the benefits of Pentapeptide-18 may persist even after discontinuing its use, indicating potential long-term anti-aging effects.

To achieve the best results, it is important to follow proper application techniques and adhere to recommended dosage guidelines. Additionally, combining Pentapeptide-18 with other complementary skincare products or treatments may further enhance its efficacy.

11. Where to Buy Pentapeptide-18 (Leuphasyl) (Topical)?

Pentapeptide-18 (Leuphasyl) for non-human research purposes can be purchased from reputable peptide suppliers such as It is essential to ensure that the supplier adheres to strict quality control measures and provides peptides that meet industry standards.

ResearchPeptides is known for its commitment to providing high-quality peptides for research purposes. They offer a range of peptides, including Pentapeptide-18, with detailed product information and documentation to support their authenticity and purity.

When purchasing peptides for research, it is crucial to comply with all legal and ethical guidelines pertaining to their use.

12. Pentapeptide-18 (Leuphasyl) (Topical) for Sale

Pentapeptide-18 (Leuphasyl) is available for purchase from, a trusted supplier of research peptides. The price and availability may vary depending on the quantity and specific requirements of the researcher. ensures that all peptides undergo rigorous testing to ensure purity, potency, and quality. They provide detailed product information, including certificates of analysis, to guarantee the authenticity and integrity of their peptides.

Researchers should exercise caution when purchasing peptides and only obtain them from reputable sources that prioritize product quality and adhere to legal and ethical standards.

Pentapeptide-18 (Leuphasyl) has demonstrated promising results in numerous studies, showcasing its potential as a topical solution. Its ability to reduce the appearance of wrinkles and fine lines has been consistently observed, suggesting its effectiveness in promoting youthful skin. With further research and development, Pentapeptide-18 holds great promise for individuals seeking a reliable and efficient anti-aging solution.

Frequently Asked Questions About Pentapeptide-18 (Leuphasyl) (Topical) Peptides February 2024

What is the use of pentapeptide?

One commercially available pentapeptide is called palmitoyl pentapeptide-4, which is trademarked as Matrixyl. It is used as an ingredient in anti-wrinkle cosmetics. This compound is composed of five amino acids (lysine, threonine, threonine, lysine, and serine) linked to palmitoyl.

What peptides grow eyelashes?

Myristoyl pentapeptide-17 is a highly effective ingredient found in eyelash growth serums. It has been proven to increase the production of keratin, which is the protein responsible for hair growth, and also extend the duration of the hair growth cycle.

What is the name of the pentapeptide-18?

Leuphasyl® is a substance that is made up of five amino acids and is also known as Pentapeptide-18 with the sequence Tyr-D-Ala-Gly-Phe-Leu. It has the ability to regulate Ca2+ channels in test tube environments. This substance is similar to enkephalin and has been found to be successful in reducing the appearance of expression wrinkles in a different way than Botulinum toxin-like substances.

Is peptide cream good for face?

According to Dr. Ariel Ostad, a certified dermatologist and cosmetic surgeon, peptides have the ability to boost collagen production, enhance elasticity, minimize the appearance of fine lines and wrinkles, prevent pore blockage by bacteria, and strengthen the skin’s protective barrier.

What does pentapeptide-18 do?

Pentapeptide-18 is a type of peptide that has been extensively researched for its potential to decrease the signs of aging, such as reducing the visibility of expression lines and decreasing the depth of wrinkles. It is often referred to as a “neuropeptide” in scientific studies, with “neuro” relating to nerves.

What is topical application of peptides?

Peptides are essential amino acids that form the foundation of specific proteins necessary for healthy skin, such as collagen and elastin. Utilizing a serum or moisturizer rich in peptides can result in firmer, more youthful skin, and potentially reduce instances of breakouts.

Unlocking the Peptide Potential: Your Research Hub 2024

Explore a wide range of peptide forms including amino acid polymers, combined peptides, IGF-1 Proteins, Melanotan compounds, and skincare peptides at our US Peptides Shop. Dive deeper into peptide science with our Buy Research Peptides platform. We also provide a selection of Laboratory apparatus for your research needs. Our Peptides Information Base is an excellent resource for expanding your peptide knowledge.

Author Info and References

Author Info

The information provided in this article was taken from studies carried out by recognized researchers, including M. G. Normatov, V. Karev, Andrey Victorovich Kolobov, V. Mayevskaya, V. Ryabkova, Vladimir Josefovich Utekhin, L. Churilov, J. Adcock, C. Schneider, T. Smith, Rui Tang, Jianpeng Xue, Baogang Xu, Duanwen Shen, G. Sudlow, S. Achilefu, Jisu Park, Hyejung Jung, Bohee Jang, Hyun-Kuk Song, I. Han, and E. Oh.


  1. Normatov, M. G., Karev, V., Kolobov, A. V., Mayevskaya, V., Ryabkova, V., Utekhin, V. J., & Churilov, L. (2023). Post-COVID Endocrine Disorders: Putative Role of Molecular Mimicry and Some Pathomorphological Correlates. Diagnostics.
  2. Adcock, J., Schneider, C., & Smith, T. (1988). Effects of codeine, morphine and a novel opioid pentapeptide BW443C, on cough, nociception and ventilation in the unanaesthetized guinea-pig. British Journal of Pharmacology.
  3. Tang, R., Xue, J., Xu, B., Shen, D., Sudlow, G., & Achilefu, S. (2015). Tunable Ultrasmall Visible-to-Extended Near-Infrared Emitting Silver Sulfide Quantum Dots for Integrin-Targeted Cancer Imaging. ACS Nano.
  4. Park, J., Jung, H., Jang, B., Song, H. K., Han, I., & Oh, E. (2020). D-tyrosine adds an anti-melanogenic effect to cosmetic peptides. Scientific Reports.

Pentapeptide18 Leuphasyl Research Peptides Scientists

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Cite this article as: Research Peptides Scientist, "Pentapeptide-18 (Leuphasyl) 200mg (Topical)," in, November 5, 2023, Accessed February 29, 2024.


Product Usage: THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. This product has not been approved by the FDA for Human Use. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.


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