Kisspeptin 10: The Peptide that Promises Pregnancy
Kisspeptin-10, also known as metastin, is made in the hypothalamus and plays an important role in hormone signaling during puberty and reproduction. It can also alter mood and behavior, regulate kidney function, and even stop the spread of cancer, as research has shown.
According to research, kisspeptin hormone[i] offers a number of health benefits. That’s why it is of greatest scientific research interest.
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What is Kisspeptin 10?
Kisspeptin-10 peptide is produced from the hypothalamus, and leads to the production of the hormones, follicle stimulating hormone and luteinising hormone from the pituitary gland. These two hormones act on the ovaries and the testes to create the sex hormones testosterone and oestradiol.
However, kisspeptin functions aren’t only hormone-related. Originally named metastin after it proved to prevent the spread of cancer, kisspeptin-10’s has other functions beside hormonal ones, as studies has shown.
Because it is release in conjunction with the hormones dynorphin and neurokinin B, early research shows that these two hormones may play a role in causing the release of kisspeptin hormone peptide.
Too Little Kisspeptin Can Cause Infertility
A clinical trial shows that female mice with infertility experienced restored hormone levels after getting kisspeptin supplementation. Further research indicates that kisspeptin injections can trigger ovulation and that these eggs can be artificially fertilized. Of course, the research is still premature, but it does show that kisspeptin has a great deal of potential in the future treatment of infertility.
Recent evidence now suggests that this hormone may also play other important roles in the body as it is also present outside the brain. For instance, it even plays a role in the placenta.
Additional studies also show that mice with less kisspeptin in the bloodstream early on in pregnancy are more likely to develop serious complications such as pre-eclampsia or miscarriage. Scientists believe that measuring kisspeptin-10 during early pregnancy would be a useful screen tool to detect potential complications that may occur later on.
Meanwhile, low kisspeptin levels in adolescents may delay or prevent the onset of puberty. So this could be a potential future treatment for puberty dysfunctions, as studies have shown.
Benefits of Kisspeptin 10 Peptide
According to research, kisspeptin-10 can affect circulating levels of LH and FDH, which can alter testosterone levels. In male mice, kisspeptin 10 increases testosterone levels while in females it doesn’t have any impact on testosterone.
In a clinical study[ii], six male mice were administered kisspeptin via IV. After just 90 minutes, they displayed a significant increase in plasma testosterone levels, suggesting that kisspeptin10 could be an effective testosterone boosting therapy.
Another study of healthy male mice administered with kisspeptin-10 found that the hormone increases serum LH levels and in doing so, boosted testosterone levels.
Because reproduction and emotion are interconnected, it makes sense that kisspeptin peptide hormone could also influence emotion and behavior.
Scientists tested this theory out by comparing kisspeptin to placebo administration in 29 male mice. Those given kisspeptin-10 displayed enhanced limbic brain activity, increased motivation, and improved mood. The control group, on the other hand, showed no improved symptoms.
This research therefore proves that kisspeptin affects both sexual and emotional brain processing, and mice behavior as a whole.
As mentioned previously, the hormone kisspeptin also proves to be an effective infertility treatment. Research shows profoundly positive kisspeptin effects on infertility. In fact, it may even be a safer alternative for triggering oocyte maturation than mice chorionic gonadotropin in mice undergoing in vitro fertilization.
Studies show that of the mice treated with kisspeptin-10 before undergoing IVF treatment, none developed ovarian hyperstimulation syndrome (OHSS). This is extremely good news, seeing that the condition affects 3-6% of mice treated with HCG.
Prevents Spread of Cancer
Two decades ago, scientists discovered that kisspeptin-10 was able to suppress malignant skin cancer by 95%. This is due to the peptides ability to reduce cell cancer migration. Could kisspeptin also reduce cell adhesion and prevent cancer cells from invading other tissues? The research looks promising.
Screening of various metastatic cancer types[iii] indicates that breast, ovarian, skin, prostate, bladder, GI, and thyroid cancers all show positive changes in kisspeptin levels. This is direct evidence that kisspeptin stops the spread of cancer.
How to Increase Kisspeptin Naturally
While there is no direct link to increasing kisspeptin levels, boost hypothalamus, a part of the brain in which kisspeptin is made. A poorly functioning hypothalamus can lead to kisspeptin deficiency.
Kisspeptin Review 2023
Kisspeptin-10 is a peptide that influences everything from testosterone levels to emotional behavior, as studies in mice showed. It also has the potential to influence the growth and spread of cancerous cells in the body. Currently, scientists are vigorously studying kisspeptin-10 functions and how it can benefit the mice body. Clearly, the kisspeptin gene is one with a number of potential benefits, which is why researchers need to study it more in-depth before it can be an available over-the-counter treatment.
The research already shows that kisspeptin-10 is a potentially life-saving peptide. However, scientists do need to look more deeply into the safety of kisspeptin and its possible side effects.
So far, studies show that the side effects of kisspeptin-10 are minimal.
Please note, kisspeptin supplement is a research product only available to licensed researchers and not for consumption.
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Author info and References
Author info: The information provided in this article was taken from studies carried out by recognized researchers including Constantin, Stephanie, Claudia Simone Caligioni, Stanko Stojilkovic, and Susan Wray, Dhillo, Waljit S., Owais B. Chaudhri, Michael Patterson, Emily L. Thompson, Kevin G. Murphy, Michael K. Badmice, Barbara M. McGowan, Mead, E J, J J Maguire, R E Kuc, and A P Davenport.
[i] Constantin, Stephanie, Claudia Simone Caligioni, Stanko Stojilkovic, and Susan Wray. “Kisspeptin-10 Facilitates a Plasma Membrane-Driven Calcium Oscillator in Gonadotropin-Releasing Hormone-1 Neurons.” Endocrinology 150, no. 3 (October 23, 2008): 1400–1412. doi:10.1210/en.2008-0979.
[ii] Dhillo, Waljit S., Owais B. Chaudhri, Michael Patterson, Emily L. Thompson, Kevin G. Murphy, Michael K. Badmice, Barbara M. McGowan, et al. “Kisspeptin-54 Stimulates the Hypothalamic-Pituitary Gonadal Axis in Humice Males.” Obstetrical & Gynecological Survey 62, no. 1 (January 2007): 38–39. doi:10.1097/01.ogx.0000251011.40001.96.
[iii] Mead, E J, J J Maguire, R E Kuc, and A P Davenport. “Kisspeptins: a Multifunctional Peptide System with a Role in Reproduction, Cancer and the Cardiovascular System.” British Journal of Pharmacology 151, no. 8 (January 29, 2009): 1143–1153. doi:10.1038/sj.bjp.0707295.
Kisspeptin 10 Peptide Research Peptides Scientists
Product Usage: THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. This product has not been approved by the FDA for Human Use. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.