Tesofensine 500mcg (30 Capsules)


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Product Description

Tesofensine Capsules

Tesofensine (NS2330) is a serotonin, dopamine, and noradrenaline reuptake inhibitor that is currently being investigated for its weight loss effects.

Initially developed for the treatment of Alzheimer’s Disease and Parkinson’s Disease, researchers noted significant weight loss in study volunteers taking the tesofensine peptide. As a result, researchers are now looking at it as a potential obesity treatment thanks to its ability to suppress appetite. Tesofensine is currently in phase III clinical trials as a weight loss treatment.

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What is Tesofensine?

Tesofensine (also known as TE) inhibits neurotransmitter presynaptic reuptake of dopamine, serotonin, and noradrenaline. When these three neurotransmitters are inhibited and prevented from re-entering the central nervous system, the body responds with a decrease in appetite.

Tensofensine functions primarily as an appetite suppressant. According to research, it also boasts other effects on fat oxidation, enhancing weight loss. Scientists say the tesofensine peptide has a modulating action on dopamine – often called the “happy hormone” – as it affects the pleasure sensation involved with food consumption.

The peptide was initially developed for the treatment of neurological disorders such as Alzheimer’s and Parkinson’s. Studies, however, found that the tesofensine effects on these conditions were relatively weak. Since then, researchers have found that weight loss was consistently reported[i] with tesofensine usage, particularly in overweight patients.

Ultimately, researchers ceased investigating it for neurological disorders and focused on studying tesofensine weight loss effects.

How Does Tesofensine Work?

As a serotonin-noradrenaline-dopamine reuptake inhibitor, the tesofensine capsules help to suppress appetite and boost metabolic rate. Studies prove tesofensine’s effectiveness in treating obesity. One study found that participants all saw a noticeable difference when taking tesofensine, including an overall 5-10% reduction in body weight. Everything from body fat to waist and hip circumference was also reduced, as was BMI.

From what research shows so far, tesofensine results go beyond weight loss benefits. Some of its reported effects include improved cognition, memory, and learning, which is why the peptide is also studied for its effects on depression and cognitive decline.

Tesofensine Benefits

While tesofensine research is still relatively limited, studies so far show that it can offer a range of benefits, especially when it comes to weight loss. The more research carried out on this peptide, the more scientists hope to discover. Here are the primary benefits of tesofensine so far, as reported by researchers.

Tesofensine for Weight Loss

Since discovering its ability to suppress appetite and aid in fat oxidation, researchers have diligently investigated the tesofensine obesity treatment.

The clinical Phase 2B trial results[ii] indicate that tesofensine produces approximately 28.2lbs of weight loss on a 1 mg dose, 24.9lbs on a 0.3 mg dose, and 14.7lbs on a 0.25 mg dose. All patients were instructed to follow a 300-calorie deficit diet and to engage in 30-60 minutes of physical exercise per day.

Research shows that tesofensine produced the best results when paired with caloric restrictions and exercise.

Other tesofensine results noted by patients include improved levels of insulin sensitivity, appetite reduction, an increase in energy after 14 days, and an increase in fat oxidation – and ultimately a reduction in fat tissue.

In the phase 3 study, a 24-week double-blinded trial, patients were given 0.25mg and 0.50mg of oral tesofensine. Results found a decrease in body weight, reduction in BMI, decreased body fat, decreased insulin, and improvements in hip and waist circumference. There was even evidence to suggest that tesofensine pills or capsules could better regulate glucose metabolism and even potentially reverse early type 2 diabetes.

From what’s been discovered at present, this peptide looks to be a ground-breaking formula when it comes to the treatment of obesity and diabetes.

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Tesofensine, a Novel Triple Monoamine Reuptake Inhibitor, Induces Appetite Suppression by Indirect Stimulation of α1 Adrenoceptor and Dopamine D1 Receptor Pathways in the Diet-Induced Obese Rat [PubMed]

Tesofensine for Depression

According to research, tesofensine may be helpful for depression. Research demonstrates that stress can decrease BDNF levels in the brain – that responsible for stimulating neuron growth and easing symptoms in those with depression and cognitive decline. When this exposure to stress becomes chronic and prolonged, atrophy of the hippocampus can occur. This change in the structure of the hippocampus has been linked to depression.

Studies show that tesofensine can improve BDNF levels and ultimately promote neurogenesis in the brain, offering anti-depressant properties. While it’s not been the primary focus of research, it’s clear that tesofensine capsules can be effective at easing mental health issues like depression.

Tesofensine for Alzheimer’s

While researchers may have abandoned the use of tesofensine in the treatment of Alzheimer’s and Parkinson’s, there’s still enough evidence to show the compound boasts beneficial effects on memory and cognition. Despite the dopamine-boosting effects being too small to have a great impact on these neurological diseases, some scientists are still interested in harnessing the peptide’s cognitive-enhancing abilities.

As previously mentioned, tesofensine peptide can increase BDNF levels. This in turn can help boost cell survival and reproduction. Experts are convinced this compound may be helpful for a range of conditions including depression, obsessive-compulsive disorder, and Alzheimer’s.

Tesofensine for Pain Management

While research is limited on these effects, there is evidence to suggest that this anti-depressant may be able to help when it comes to managing pain. Thanks to dopamine-boosting agents, tesofensine may aid in quelling pain. Of course, the current research focus is on its ability to boost weight loss. That said, scientists do believe they’ll find more benefits of tesofensine the more they investigate the compound.

Tesofensine Side Effects

Is tesofensine safe? The side effects of tesofensine are much like any other dietary pills and weight loss medications. In clinical trials, the most common tesofensine peptide side effects included dry mouth, nausea, insomnia, constipation, diarrhea, and high blood pressure.

According to researchers, anti-obesity drugs are known for posing cardiovascular risks. Compared to many of these drugs, however, tesofensine is relatively safe. It is unique in that it acts on the neurotransmitter reuptake instead of the peripheral action of lipase inhibitors and other compounds.

Is tesofensine dangerous? From what scientists have discovered so far, it is not considered harmful to health.

How to Take Tesofensine

In regards to tesofensine dosage, researchers have used a variety on test subjects. The most effective tesofensine dose is between 0.5 and 1 mg, taken once per day. This is the safest way to take tesofensine without experiencing unpleasant side effects.

Since this peptide is not yet approved for human consumption, we are unable to provide detailed information regarding dosage.

When to Take Tesofensine

In studies, participants received tesofensine once a day. Research shows that it performs best when combined with a low-calorie diet and exercise.

Since this peptide is not currently approved for human consumption, we are unable to provide detailed information regarding tesofensine when to take.


Tesofensine Peptide
Quantitative Pharmacology Approach in Alzheimer’s Disease: Efficacy Modeling of Early Clinical Data to Predict Clinical Outcome of Tesofensine. [PubMed]

Tesofensine vs Semaglutide

Semaglutide is an FDA-approved medication known for its weight loss benefits. It functions by mimicking glucagon-like peptide-1 (GLP-1), a hormone that’s produced naturally in the body. With the release of this hormone, it targets receptors in the body that spur insulin release while simultaneously suppressing glucagon, thereby decreasing appetite. Originally developed to aid with type 2 diabetes, GLP-1 receptors are now commonly used for treating obesity.

Tesofensine is also an appetite suppressant. However, it functions in a differently than semaglutide. Tesofensine inhibits presynaptic reuptake of dopamine, serotonin, and noradrenaline, which causes the body to feel naturally fuller. This in turn leads to significant fat loss.

While tesofensine and semaglutide are both effective when it comes to promoting weight loss, tesofensine FDA approval hasn’t yet been confirmed. That said, research shows that tesofensine is highly effective in regards to triggering significant weight loss.

Tesofensine Reviews

There’s a great deal of positive research regarding tesofensine peptide. While it was originally designed to treat neurological conditions, scientists have now focused their research on the compound’s appetite-suppressing effects. These effects can lead to profound weight loss, which researchers find compelling and want to investigate further.

From what studies show, tesofensine before and after results show a significant improvement in weight loss and BMI, especially in obese and overweight patients. While you can read tesofensine Reddit reviews, the clinical research shows you everything you need to know about this promising weight loss medication.

Its primary benefit is stimulating weight loss, which is achieved by suppressing appetite. Alongside this, tesofensine capsules can be beneficial in preventing type 2 diabetes, treating depression, and improving cognitive health.

If you are a medical researcher interested in studying this compound, you can buy tesofensine online. Tesofensine price is approximately $250. It is always best to purchase high-quality products for your research to get the best possible results. There are only a select few tesofensine 2021 suppliers that we recommend. Avoid choosing the low cost versions, as these tend to be of poor quality, which can affect the outcome of your research.

Where to Buy Tesofensine

Researchers are convinced that tesofensine will be a groundbreaking weight loss drug. While clinical trials continue, research already supports its effectiveness with regards to promoting fat loss and improving mental health. Some studies suggest it can help prevent type 2 diabetes.

Is tesofensine available online? Yes, you can buy tesofensine peptide from several online retailers. However, you must purchase with caution to prevent getting poor quality product. When looking for tesofensine peptide for sale, always do your research and stick to a well-known, respected supplier. This way, you’ll be guaranteed the highest quality product and the best outcome for your research project.

Are you interested in tesofensine buy online USA for your research? With offices in California, we can deliver straight to your door – no matter where you are in the world. Simply place your order, add in your details, and we’ll dispatch your order within 1-2 days.

Tesofensine Buy Online

When choosing tesofensine for sale, it’s imperative to choose a company with a solid reputation and professional work ethic. As a researcher, it’s crucial that you use only the best quality tesofensine available for your projects to guarantee the most accurate results.

Researchers favor Peptide Sciences Tesofensine for its overall quality and price. We always strive to deliver the best products and services to clients. The medical community relies on us for our research compounds for their research. So, if you’re looking for tesofensine peptide buy, get it directly from our store.

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Tesofensine for Research

Tesofensine is an innovative inhibitor of the reuptake of dopamine, serotonin, and norepinephrine. By boosting levels of these neurotransmitters, tesofensine peptide increases BDNF expression patterns and ultimately aids in reducing feelings of hunger, leading to weight loss.

Research also shows that tesofensine may help treat a range of neurological conditions including depression, schizophrenia, and Alzheimer’s Disease. Further studies suggest it may also improve blood glucose levels and even reverse type 2 diabetes.

As impressive as tesofensine weight loss effects are, it may prove to be even more outstanding by helping to interpret the connection between the gut and brain that controls eating behavior.

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Author info: The information provided in this article was taken from studies carried out by recognized researchers including Astrup A, Meier DH, Mikkelsen BO, Villumsen JS, Larsen TM, Sten Madsbad, Leif Breum, Thomas J Jensen, and Jens Peter Kroustrup.



[i] Astrup A, Meier DH, Mikkelsen BO, Villumsen JS, Larsen TM. Weight loss produced by tesofensine in patients with Parkinson’s or Alzheimer’s disease. Obesity (Silver Spring). 2008 Jun;16(6):1363-9. doi: 10.1038/oby.2008.56. Epub 2008 Mar 20. PMID: 18356831.

[ii] Astrup, Arne, Sten Madsbad, Leif Breum, Thomas J Jensen, Jens Peter Kroustrup, and Thomas Meinert Larsen. “Effect of Tesofensine on Bodyweight Loss, Body Composition, and Quality of Life in Obese Patients: A Randomised, Double-Blind, Placebo-Controlled Trial.” The Lancet 372, no. 9653 (November 2008): 1906–13. https://doi.org/10.1016/s0140-6736(08)61525-1.


Cite this article as: Research Peptides Scientists, “Tesofensine 500mcg (30 Capsules),” in ResearchPeptides.net, October 29, 2022, https://researchpeptides.net/product/peptides/tesofensine-500mcg-30-capsules/.


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Product Usage: THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. This product has not been approved by the FDA for Human Use. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.


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Tesofensine 500mcg (30 Capsules)


30 Capsules




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